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Elastogenesis in human arterial disease: A role for macrophages in disordered elastin synthesis
Brigham and Women's Hospital, Harvard Medical School, Boston, United States.ORCID-id: 0000-0002-4583-9315
Brigham and Women's Hospital, Harvard Medical School, Boston, United States.
Brigham and Women's Hospital, Harvard Medical School, Boston, United States.
2003 (Engelska)Ingår i: Arteriosclerosis, Thrombosis and Vascular Biology, ISSN 1079-5642, E-ISSN 1524-4636, Vol. 23, nr 4, s. 582-587Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

OBJECTIVE: Elastin, an extracellular matrix protein, constitutes about 30% of the dry weight of the arteries. Elastolysis induced by inflammatory processes is active in chronic arterial diseases. However, elastogenesis in arterial diseases has received little attention. In this work we hypothesized that disordered elastogenesis is active in matrix remodeling in atheroma and abdominal aortic aneurysm (AAA).

METHODS AND RESULTS: Human AAA and atheroma have 4- to 6-fold more tropoelastin protein than nondiseased arteries. The smooth muscle cell-containing media and fibrous cap of atherosclerotic arteries contain ordered mature elastin, whereas macrophage (MPhi)-rich regions often have disorganized elastic fibers. Surprisingly, in addition to smooth muscle cells, MPhis in diseased arteries also produce the elastin precursor tropoelastin, as shown by double immunostaining, in situ hybridization, and reverse transcription-polymerase chain reaction for tropoelastin mRNA. Cultured monocyte-derived MPhis can express the elastin gene. AAA have 9-fold but atheroma only 1.6-fold lower levels of desmosine, a marker for mature cross-linked elastin, than normal arteries.

CONCLUSIONS: This study demonstrates ongoing but often ineffective elastogenesis in arterial disease and establishes human macrophages as a novel source for this important matrix protein. These results have considerable import for understanding mechanisms of extracellular matrix remodeling in arterial diseases.

Ort, förlag, år, upplaga, sidor
Lippincott Williams & Wilkins, 2003. Vol. 23, nr 4, s. 582-587
Nyckelord [en]
AAA, Atherosclerosis, Elastin, Macrophages
Nationell ämneskategori
Annan medicinsk grundvetenskap
Forskningsämne
Medicin
Identifikatorer
URN: urn:nbn:se:his:diva-11408DOI: 10.1161/01.ATV.0000064372.78561.A5ISI: 000182165100009PubMedID: 12615674Scopus ID: 2-s2.0-0037389189OAI: oai:DiVA.org:his-11408DiVA, id: diva2:848233
Tillgänglig från: 2015-08-24 Skapad: 2015-08-24 Senast uppdaterad: 2018-01-11Bibliografiskt granskad

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