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A Mathematical Framework for Analyzing T Cell Receptor Scanning of Peptides
Högskolan i Skövde, Forskningscentrum för Systembiologi. Högskolan i Skövde, Institutionen för vård och natur.
2010 (Engelska)Ingår i: Biophysical Journal, ISSN 0006-3495, E-ISSN 1542-0086, Vol. 99, nr 9, s. 2717-2725Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

T cells continuously search for antigenic peptides presented on major histocompatibility complexes expressed on nearly all nucleated cells. Because only a few antigenic peptides are presented in a sea of thousands of self-peptides, the T cells have a critical task in discriminating between self- and nonself-peptides. This search process for antigens must be performed with sufficient speed in order to induce a fast response against invading pathogens. This study presents a mathematical framework for analyzing the scanning process of peptides. The framework includes analytic expressions for calculating the sampling rate as well as continuous-systems- and stochastic-agent-based models. The results show that the scanning of self-peptides is a very fast process due to fast off-rates. The simulations also predict the existence of an optimal sampling rate for a certain range of on-rates based on the recently proposed confinement time model. Calculations reveal that most of the self-peptides located within a microdomain are scanned within just a few seconds, and that the T cell receptors have kinetics for self-peptides, facilitating fast scanning. The derived mathematical expressions within this study provide conceptual calculations for further investigations of how the T cell discriminates between self- and nonself-peptides.

Ort, förlag, år, upplaga, sidor
The Biophysical Society , 2010. Vol. 99, nr 9, s. 2717-2725
Nationell ämneskategori
Naturvetenskap
Forskningsämne
Naturvetenskap
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URN: urn:nbn:se:his:diva-4697DOI: 10.1016/j.bpj.2010.08.024ISI: 000283912600005PubMedID: 21044568Scopus ID: 2-s2.0-78249287282OAI: oai:DiVA.org:his-4697DiVA, id: diva2:393909
Tillgänglig från: 2011-02-01 Skapad: 2011-02-01 Senast uppdaterad: 2017-12-11Bibliografiskt granskad

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