his.sePublikasjoner
Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
A miRNA expression signature that separates between normal and malignant prostate tissues
Högskolan i Skövde, Institutionen för vård och natur. Högskolan i Skövde, Forskningscentrum för Systembiologi.
Orebro Univ Hosp, Dept Urol, Orebro, Sweden / Univ Orebro, Sch Hlth & Med Sci, Orebro, Sweden.
Orebro Univ Hosp, Dept Lab Med, Orebro, Sweden.
Orebro Univ Hosp, Dept Lab Med, Orebro, Sweden.
Vise andre og tillknytning
2011 (engelsk)Inngår i: Cancer Cell International, ISSN 1475-2867, E-ISSN 1475-2867, Vol. 11, s. 14-Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Background: MicroRNAs (miRNAs) constitute a class of small non-coding RNAs that post-transcriptionally regulate genes involved in several key biological processes and thus are involved in various diseases, including cancer. In this study we aimed to identify a miRNA expression signature that could be used to separate between normal and malignant prostate tissues. Results: Nine miRNAs were found to be differentially expressed (p < 0.00001). With the exception of two samples, this expression signature could be used to separate between the normal and malignant tissues. A cross-validation procedure confirmed the generality of this expression signature. We also identified 16 miRNAs that possibly could be used as a complement to current methods for grading of prostate tumor tissues. Conclusions: We found an expression signature based on nine differentially expressed miRNAs that with high accuracy (85%) could classify the normal and malignant prostate tissues in patients from the Swedish Watchful Waiting cohort. The results show that there are significant differences in miRNA expression between normal and malignant prostate tissue, indicating that these small RNA molecules might be important in the biogenesis of prostate cancer and potentially useful for clinical diagnosis of the disease.

sted, utgiver, år, opplag, sider
BioMed Central, 2011. Vol. 11, s. 14-
HSV kategori
Forskningsprogram
Medicin
Identifikatorer
URN: urn:nbn:se:his:diva-5544DOI: 10.1186/1475-2867-11-14ISI: 000292110200001Scopus ID: 2-s2.0-79957484812OAI: oai:DiVA.org:his-5544DiVA, id: diva2:508734
Tilgjengelig fra: 2012-03-09 Laget: 2012-03-01 Sist oppdatert: 2017-12-07bibliografisk kontrollert

Open Access i DiVA

Carlsson_et_al_2011(431 kB)661 nedlastinger
Filinformasjon
Fil FULLTEXT01.pdfFilstørrelse 431 kBChecksum SHA-512
c6e7882655f1b3d7af47086418819433ad8dcc43c9dd060d1ae3fc7247ba24a5c836fa45eb9ea0b1c1617b51d4fd55423e108722fad75f5ec2685f2dfc4e87fd
Type fulltextMimetype application/pdf

Andre lenker

Forlagets fulltekstScopus

Personposter BETA

Carlsson, JessicaLubovac, ZelminaOlsson, BjörnKlinga-Levan, Karin

Søk i DiVA

Av forfatter/redaktør
Carlsson, JessicaLubovac, ZelminaOlsson, BjörnKlinga-Levan, Karin
Av organisasjonen
I samme tidsskrift
Cancer Cell International

Søk utenfor DiVA

GoogleGoogle Scholar
Totalt: 661 nedlastinger
Antall nedlastinger er summen av alle nedlastinger av alle fulltekster. Det kan for eksempel være tidligere versjoner som er ikke lenger tilgjengelige

doi
urn-nbn

Altmetric

doi
urn-nbn
Totalt: 1504 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf