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High-resolution genomic profiling to predict 10-year overall survival in node-negative breast cancer
University of Gothenburg.
University of Gothenburg.
University of Gothenburg.
University of Gothenburg.
Vise andre og tillknytning
2010 (engelsk)Inngår i: Cancer Genetics and Cytogenetics, ISSN 2210-7762, E-ISSN 2210-7770, Vol. 198, nr 2, s. 79-89Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Women with clinically node-negative breast cancer have a better prognosis than do those with axillary lymph node metastasis. Nonetheless, ~20% of node-negative patients die within 15 years of diagnosis, and thus additional prognostic markers are greatly needed. To identify specific copy number alterations (CNAs) that differed in frequency between 10-year survivors and deceased patients with node-negative breast cancer, array comparative genomic hybridization (aCGH) was applied to 41 primary node-negative breast tumors. Fisher's exact test was used to identify significantly different CNAs between 10-year survivors and deceased patients. Losses at 8p21.2~p21.3, 8p23.1~p23.2, Xp21.3, and Xp22.31~p22.33 were significantly more common in tumors from deceased patients, suggesting that these alterations may contribute to tumor aggressiveness. Gains at 1q25.2~q25.3 and 1q31.3~q41 were more prevalent in tumors from survivors; specific gains at these genomic regions may inhibit further tumor progression, resulting in a less aggressive form of node-negative breast cancer. Evaluation of the identified CNAs in an independent external data set verified the prognistic potential of the 1q31.3~q41 region. Although further extensive validation is needed, the prognostic CNAs identified in this work may in time facilitate the clinical assessment of breast cancer.

sted, utgiver, år, opplag, sider
Elsevier, 2010. Vol. 198, nr 2, s. 79-89
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Naturvetenskap
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URN: urn:nbn:se:his:diva-4497DOI: 10.1016/j.cancergencyto.2009.12.012ISI: 000276781000001PubMedID: 20362222Scopus ID: 2-s2.0-77950856355OAI: oai:DiVA.org:his-4497DiVA, id: diva2:381395
Tilgjengelig fra: 2010-12-27 Laget: 2010-12-27 Sist oppdatert: 2017-12-11bibliografisk kontrollert

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