his.sePublikasjoner
Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Importance of FAS-1377, FAS-670 and FASL-844 Polymorphisms in Tumor Onset, Progression and Pigment Phenotypes of Swedish Patients With Melanoma: A Case-Control Analysis
Högskolan i Skövde, Institutionen för vård och natur.
Department of Biomedicine and Surgery, Faculty of Health Sciences, Linköping University, Linköping, Sweden.
Division of Dermatology, Department of Clinical and Experimental Medicine, Linköping University, Sweden.
Division of Dermatology, Department of Clinical and Experimental Medicine, Linköping University, Sweden.
2007 (engelsk)Inngår i: The Cancer Journal, ISSN 1528-9117, E-ISSN 1540-336X, Vol. 13, nr 4, s. 233-237Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

PURPOSE: Human skin melanoma at later stages usually has an extremely poor prognosis. It is of importance to search for biologic markers to identify and monitor individuals at risk for melanoma for early diagnosis and to avoid tumor progression. The FAS gene and its natural ligand (FASL) gene initiate the death signal cascade, playing a central role in the apoptotic signaling pathway and tumor growth and metastasis. PATIENTS AND METHODS: In this study, we analyzed polymorphisms in 229 patients with melanoma and 351 age- and gender-matched tumor-free individuals. Genomic DNAs were isolated from mononuclear cells in peripheral vein blood, and the polymorphisms were examined with polymerase chain reaction-restriction fragment length polymorphism techniques. Frequency in distribution of the polymorphisms was compared between the patients with melanoma and the healthy control subjects, and associations with patients' pigment phenotypes, age at diagnosis, and melanoma characteristics were analyzed. RESULTS AND CONCLUSIONS: The FAS-1377, FAS-670, and FASL-844 polymorphisms were not found to be markers of melanoma risk (P > 0.05). In patients with melanoma, frequencies of the FAS-1377, FAS-670, and FASL-844 polymorphisms were different between the patients aged <50 and > or =50 years (P < or = 0.025, P < or = 0.025, and P < or = 0.01). Moreover, the FAS-670 polymorphism correlated with tumor Breslow thickness (P < or = 0.01) and Clark level (P < or = 0.001) and was associated with tumors developing in sun-exposed locations (P < or = 0.001). FAS and FASL were not markers for melanoma risk but might be important in the development and progression of sun-induced melanoma independently of skin type.

sted, utgiver, år, opplag, sider
Lippincott Williams & Wilkins, 2007. Vol. 13, nr 4, s. 233-237
HSV kategori
Forskningsprogram
Medicin
Identifikatorer
URN: urn:nbn:se:his:diva-2184DOI: 10.1097/PPO.0b013e318046f214ISI: 000248665100004PubMedID: 17762757Scopus ID: 2-s2.0-35748938818OAI: oai:DiVA.org:his-2184DiVA, id: diva2:32460
Tilgjengelig fra: 2008-06-12 Laget: 2008-06-12 Sist oppdatert: 2017-12-12bibliografisk kontrollert

Open Access i DiVA

Fulltekst mangler i DiVA

Andre lenker

Forlagets fulltekstPubMedScopushttp://www.ncbi.nlm.nih.gov/pubmed/17762757?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus

Personposter BETA

Zhang, Hong

Søk i DiVA

Av forfatter/redaktør
Zhang, Hong
Av organisasjonen
I samme tidsskrift
The Cancer Journal

Søk utenfor DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric

doi
pubmed
urn-nbn
Totalt: 216 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf