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Ranking the relevance of genes targeted by cancer-associated MiRNAs
Högskolan i Skövde, Institutionen för vård och natur. (Bioinformatik)
2008 (engelsk)Independent thesis Advanced level (degree of Master (One Year)), 10 poäng / 15 hpOppgave
Abstract [en]

MicroRNAs control the expression of their target genes by translational repression.

They are involved in various biological processes including cancer progression.

To uncover the biological role of microRNAs it is necessary to identify their

target genes. The small number of experimentally validated target genes makes

computer prediction methods very important. However, state of the art prediction

tools result in a great number of putative targets. The number of false positives

among those putative targets is unknown. This report proposes, investigates and

analyses two ways of ranking the biological relevance of putative targets of miRNAs

which are associated with breast cancer.

One approach characterises values of network properties of the putative microRNA

targets in the human Protein-Protein Interaction network and compares

them to network property values of validated microRNA targets. Using these results

we suggest a simple approach for ranking the relevance of putative targets.

The approach consists of testing if a network property value of a putative target

differs from the mean value of the network. In addition we study which network

property contributes most to ranking using this approach.

The second approach identifies commonly overrepresented Gene Ontology categories

among putative microRNA targets, validated targets and known breast

cancer genes. We investigate possibilities to use the occurrence of a putative target

in these categories to rank its biological relevance.

Finally we present a number of genes with interesting features considering both

approaches. These genes might play a role in breast cancer progression and might

be worth investigating further.

sted, utgiver, år, opplag, sider
2008. , s. 54
Identifikatorer
URN: urn:nbn:se:his:diva-3576OAI: oai:DiVA.org:his-3576DiVA, id: diva2:288186
Presentation
(engelsk)
Uppsök
Life Earth Science
Veileder
Examiner
Tilgjengelig fra: 2010-01-21 Laget: 2010-01-20 Sist oppdatert: 2010-01-21bibliografisk kontrollert

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