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Using an ontology to enhance metabolic or signaling pathway comparisions by biological and chemical knowledge
Högskolan i Skövde, Institutionen för kommunikation och information.
2006 (engelsk)Oppgave
Abstract [en]

Motivation:

As genome-scale efforts are ongoing to investigate metabolic networks of miscellaneous organisms the amount of pathway data is growing. Simultaneously an increasing amount of gene expression data from micro arrays becomes available for reverse engineering, delivering e.g. hypothetical regulatory pathway data. To avoid outgrowing of data and keep control of real new informations the need of analysis tools arises. One vital task is the comparison of pathways for detection of similar functionalities, overlaps, or in case of reverse engineering, detection of known data corroborating a hypothetical pathway. A comparison method using ontological knowledge about molecules and reactions will feature a more biological point of view which graph theoretical approaches missed so far. Such a comparison attempt based on an ontology is described in this report.

Results:

An algorithm is introduced that performs a comparison of pathways component by component. The method was performed on two selected databases and the results proved it to be not satisfying using it as stand-alone method. Further development possibilities are suggested and steps toward an integrated method using several approaches are recommended.

Availability:

The source code, used database snapshots and pictures can be requested from the author.

sted, utgiver, år, opplag, sider
Skövde: Institutionen för kommunikation och information , 2006. , s. 17
HSV kategori
Identifikatorer
URN: urn:nbn:se:his:diva-32OAI: oai:DiVA.org:his-32DiVA, id: diva2:2683
Presentation
(engelsk)
Uppsök
Physics, Chemistry, Mathematics
Veileder
Examiner
Tilgjengelig fra: 2006-11-06 Laget: 2006-11-06 Sist oppdatert: 2018-01-12

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