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Reference values for leptin and adiponectin in children below the age of 10 based on the IDEFICS cohort
Univ Pecs, Dept Paediat, H-7623 Pecs, Hungary.
Leibniz Inst Prevent Res & Epidemiol BIPS, Bremen, Germany.
Leibniz Inst Prevent Res & Epidemiol BIPS, Bremen, Germany.;Univ Bremen, Fac Math & Comp Sci, Inst Stat, D-28359 Bremen, Germany.
CNR, Inst Food Sci, Epidemiol & Populat Genet, Avellino, Italy.
Vise andre og tillknytning
2014 (engelsk)Inngår i: International Journal of Obesity, ISSN 0307-0565, E-ISSN 1476-5497, Vol. 38, s. S32-S38Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

OBJECTIVE: To establish age- and sex-specific reference values for serum leptin and adiponectin in normal-weight 3.0-8.9-year old European children. SUBJECTS AND METHODS: Blood samples for hormone analysis were taken from 1338 children of the IDEFICS (Identification and prevention of Dietary-and lifestyle-induced health Effects in Children and infantS) study cohort. Only normal-weight children aged 3.0-8.9 years were included (n = 539) in our analysis. Using the General Additive Model for Location Scale and Shape, age-and sex-specific percentiles were derived. The influence of under/overweight and obesity on the proposed reference curves based on normal-weight children was investigated in several sensitivity analyses using the sample without obese children (n = 1015) and the whole study sample (n = 1338). RESULTS: There was a negative age trend of adiponectin blood levels and a positive trend of leptin levels in boys and girls. Percentiles derived for girls were generally higher than those obtained for boys. The corresponding age-specific differences of the 97th percentile ranged from -2.2 to 4.6 mu g ml(-1) and from 2.2 to 4.8 ng ml(-1) for adiponectin and leptin, respectively. CONCLUSIONS: According to our knowledge, these are the first reference values of leptin and adiponectin in prepubertal, normal-weight children. The presented adiponectin and leptin reference curves may allow for a more differentiated interpretation of children's hormone levels in epidemiological and clinical studies.

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Nature Publishing Group, 2014. Vol. 38, s. S32-S38
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Identifikatorer
URN: urn:nbn:se:his:diva-14435DOI: 10.1038/ijo.2014.133ISI: 000360007100005PubMedID: 25219410Scopus ID: 2-s2.0-84930800726OAI: oai:DiVA.org:his-14435DiVA, id: diva2:1157744
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Group Author(s): IDEFICS Consortium

Tilgjengelig fra: 2017-11-16 Laget: 2017-11-16 Sist oppdatert: 2017-11-27bibliografisk kontrollert

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