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Association of desaturase activity and C-reactive protein in European children
Leibniz Inst Prevent Res & Epidemiol BIPS, Bremen, Germany.
Leibniz Inst Prevent Res & Epidemiol BIPS, Bremen, Germany.
Leibniz Inst Prevent Res & Epidemiol BIPS, Bremen, Germany.
Univ Milan, Dept Pharmacol & Biomol Sci, DiSFeB, Milan, Italy.
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2017 (engelsk)Inngår i: Pediatric Research, ISSN 0031-3998, E-ISSN 1530-0447, Vol. 81, nr 1, s. 27-32Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

BACKGROUND: Desaturase enzymes influence the fatty acid (FA) composition of body tissues and their activity affects the conversion rate of saturated to monounsaturated FA and of polyunsaturated FA (PUFA) to long-chain PUFA. Desaturase activity has further been shown to be associated with inflammation. We investigate the association between delta-9 (D9D), delta-6 (D6D) and delta-5 desaturase (D5D) activity and high sensitive C-reactive protein (CRP) in young children. METHODS: In the IDEFICS (Identification and prevention of dietary- and lifestyle-induced health effects in children and infants) cohort study children were examined at baseline (TO) and after 2 y (T1). D9D, D6D, and D5D activities were estimated from TO product-precursor FA ratios. CRP was measured at TO and T1. In a subsample of 1,943 children with available information on FA, CRP, and covariates, the cross-sectional and longitudinal associations of desaturase activity and CRP were analyzed. RESULTS: Cross-sectionally, a D9D increase of 0.01 units was associated with a 11% higher risk of having a serum CRP Percentile 75 (P75) (OR, 99% CI: 1.11 (1.01; 1.22)) whereas D6D and D5D were not associated with CRP. No significant associations were observed between baseline desaturase activity and CRP 2 y later. CONCLUSION: Cross-sectionally, our results indicate a positive association of D9D and CRP independent of weight status. High D9D activity may increase the risk of subclinical inflammation which is associated with metabolic disorders. As D9D expression increases with higher intake of saturated FA and carbohydrates, dietary changes may influence D9D activity and thus CRP. However, it remains to be investigated whether there is a causal relationship between D9D activity and CRP.

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Nature Publishing Group, 2017. Vol. 81, nr 1, s. 27-32
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Identifikatorer
URN: urn:nbn:se:his:diva-14410DOI: 10.1038/pr.2016.186ISI: 000391906800005PubMedID: 27653088Scopus ID: 2-s2.0-85009815582OAI: oai:DiVA.org:his-14410DiVA, id: diva2:1157462
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Group Author(s): IDEFICS Consortium

Tilgjengelig fra: 2017-11-16 Laget: 2017-11-16 Sist oppdatert: 2017-11-27bibliografisk kontrollert

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Pala, ValeriaEiben, GabrieleAhrens, Wolfgang

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