his.sePublications
Change search
Link to record
Permanent link

Direct link
BETA
Gustafson, Deborah R.
Publications (4 of 4) Show all publications
Arnoldussen, I. A. C., Sundh, V., Bäckman, K., Kern, S., Östling, S., Blennow, K., . . . Gustafson, D. R. (2018). A 10-Year Follow-Up of Adiposity and Dementia in Swedish Adults Aged 70 Years and Older. Journal of Alzheimer's Disease, 63(4), 1325-1335
Open this publication in new window or tab >>A 10-Year Follow-Up of Adiposity and Dementia in Swedish Adults Aged 70 Years and Older
Show others...
2018 (English)In: Journal of Alzheimer's Disease, ISSN 1387-2877, E-ISSN 1875-8908, Vol. 63, no 4, p. 1325-1335Article in journal (Refereed) Published
Abstract [en]

Background: Adiposity measured in mid-or late-life and estimated using anthropometric measures such as body mass index (BMI) and waist-to-hip ratio (WHR), or metabolic markers such as blood leptin and adiponectin levels, is associated with late-onset dementia risk. However, during later life, this association may reverse and aging- and dementia-related processes may differentially affect adiposity measures.

Objective: We explored associations of concurrent BMI, WHR, and blood leptin and high molecular weight adiponectin levels with dementia occurrence.

Methods: 924 Swedish community-dwelling elderly without dementia, aged 70 years and older, systematically-sampled by birth day and birth year population-based in the Gothenburg city region of Sweden. The Gothenburg Birth Cohort Studies are designed for evaluating risk and protective factors for dementia. All dementias diagnosed after age 70 for 10 years were identified. Multivariable logistic regression models were used to predict dementia occurrence between 2000-2005, 2005-2010, and 2000-2010 after excluding prevalent baseline (year 2000) dementias. Baseline levels of BMI, WHR, leptin, and adiponectin were used.

Results: Within 5 years of baseline, low BMI (<20 kg/m(2)) was associated with higher odds of dementia compared to those in the healthy BMI category (>= 20-24.9 kg/m(2)). Compared to the lowest quartile, leptin levels in the second quartile were associated with lower odds of dementia in women (p < 0.05).

Conclusion: In late-life, anthropometric and metabolic adiposity measures appear to be differentially associated with dementia risk. While BMI and leptin levels are highly positively correlated, our results show that their association with dementia at age >= 70 years, is asynchronous. These data suggest that with aging, the complexity of the adiposity exposure may increase and suggests metabolic dysregulation. Additional studies are needed to better understand this complexity.

Place, publisher, year, edition, pages
IOS Press, 2018
Keywords
Adiponectin, body mass index, dementia, elderly, leptin, waist hip ratio
National Category
Clinical Medicine Health Sciences
Research subject
Individual and Society VIDSOC
Identifiers
urn:nbn:se:his:diva-16011 (URN)10.3233/JAD-180099 (DOI)000433970000011 ()29758945 (PubMedID)2-s2.0-85048631096 (Scopus ID)
Available from: 2018-07-23 Created: 2018-07-23 Last updated: 2018-10-23Bibliographically approved
Gustafson, D. R. & McFarlane, S. I. (2018). Epidemiology of Type 2 Diabetes and Dementia. In: Type 2 Diabetes and Dementia: (pp. 5-27). Elsevier
Open this publication in new window or tab >>Epidemiology of Type 2 Diabetes and Dementia
2018 (English)In: Type 2 Diabetes and Dementia, Elsevier, 2018, p. 5-27Chapter in book (Other academic)
Abstract [en]

Type 2 diabetes (T2D) has been associated with dementia in countless observational epidemiology studies. The expansion of epidemiologic research on T2D and dementia is due to scientific recognition of the roles of metabolic and vascular factors as etiologic players in dementia, as well as ominous global demographic shifts in aging, obesity, and dementia. This chapter addresses epidemiologic studies evaluating the association between T2D and late-onset dementias with foci on (1) T2D and dementia as syndromes; (2) T2D and mild cognitive impairment or cognition and cognitive decline; (3) vascular and metabolic risk factors and comorbidities; (4) genetic influences on the T2D-dementia association; (5) ethnoracial considerations; (6) T2D and brain outcomes and biological markers; and (7) clinical trials of T2D medications and cognition and dementia. © 2018 Elsevier Inc. All rights reserved.

Place, publisher, year, edition, pages
Elsevier, 2018
Keywords
Alzheimer, Biomarkers, Cognitive impairment, Dementia, Diabetes, Genetics, Metabolic, Vascular
National Category
Clinical Medicine
Research subject
Individual and Society VIDSOC
Identifiers
urn:nbn:se:his:diva-16060 (URN)10.1016/B978-0-12-809454-9.00002-0 (DOI)2-s2.0-85047319286 (Scopus ID)9780128096949 (ISBN)9780128094549 (ISBN)
Available from: 2018-09-10 Created: 2018-09-10 Last updated: 2018-10-23Bibliographically approved
Abulafia, C., Duarte-Abritta, B., Villarreal, M. F., Ladrón-de-Guevara, M. S., Garcia, C., Sequeyra, G., . . . Guinjoan, S. M. (2017). Relationship between Cognitive and Sleep-wake Variables in Asymptomatic Offspring of Patients with Late-onset Alzheimer's Disease. Frontiers in Aging Neuroscience, 9, Article ID 93.
Open this publication in new window or tab >>Relationship between Cognitive and Sleep-wake Variables in Asymptomatic Offspring of Patients with Late-onset Alzheimer's Disease
Show others...
2017 (English)In: Frontiers in Aging Neuroscience, ISSN 1663-4365, E-ISSN 1663-4365, Vol. 9, article id 93Article in journal (Refereed) Published
Abstract [en]

Early neuropathological changes characteristic of late-onset Alzheimer's disease (LOAD) involve brain stem and limbic structures that regulate neurovegetative functions, including sleep-wake rhythm. Indeed, sleep pattern is an emerging biomarker and a potential pathophysiological mechanism in LOAD. We hypothesized that cognitively asymptomatic, middle-aged offspring of patients with LOAD (O-LOAD) would display a series of circadian rhythm abnormalities prior to the onset of objective cognitive alterations. We tested 31 children of patients with LOAD (O-LOAD) and 19 healthy individuals without family history of Alzheimer's disease (control subjects, CS) with basic tests of cognitive function, as well as actigraphy measures of sleep-wake rhythm, cardiac autonomic function, and bodily temperature. Unexpectedly, O-LOAD displayed subtle but significant deficits in verbal episodic memory (Rey Auditory Verbal Learning Test delayed recall 10.6 +/- 0.4 vs. 8.6 +/- 0.6, t = 4.97, df = 49, p < 0.01) and language (Weschler's vocabulary 51.4 +/- 1.3 vs. 44.3 +/- 1.5, t = 2.49, df = 49, p < 0.001) compared to CS, even though all participants had results within the clinically normal range. O-LOAD showed a phase-delayed rhythm of body temperature (2.56 +/- 0.47 h vs. 3.8 +/- 0.26 h, t = 2.48, df = 40, p = 0.031). Cognitive performance in O-LOAD was associated with a series of cardiac autonomic sleep-wake variables; specifically indicators of greater sympathetic activity at night were related to poorer cognition. The present results suggest sleep pattern deserves further study as a potential neurobiological signature in LOAD, even in middle-aged, at risk individuals.

Place, publisher, year, edition, pages
Frontiers Media S.A., 2017
Keywords
early diagnosis, late-onset Alzheimer's disease, circadian rhythms, cardiac autonomic control, actigraphy
National Category
Clinical Medicine Psychology
Research subject
Individual and Society VIDSOC
Identifiers
urn:nbn:se:his:diva-13547 (URN)10.3389/fnagi.2017.00093 (DOI)000398725500001 ()28424614 (PubMedID)2-s2.0-85018442242 (Scopus ID)
Available from: 2017-05-05 Created: 2017-05-05 Last updated: 2017-11-27Bibliographically approved
Franx, B. A. A., Arnoldussen, I. A. C., Kiliaan, A. J. & Gustafson, D. R. (2017). Weight Loss in Patients with Dementia: Considering the Potential Impact of Pharmacotherapy. Drugs & Aging, 34(6), 425-436
Open this publication in new window or tab >>Weight Loss in Patients with Dementia: Considering the Potential Impact of Pharmacotherapy
2017 (English)In: Drugs & Aging, ISSN 1170-229X, E-ISSN 1179-1969, Vol. 34, no 6, p. 425-436Article, review/survey (Refereed) Published
Abstract [en]

Unintentional body weight loss is common in patients with dementia and is linked to cognitive impairment and poorer disease outcomes. It is proposed that some dementia medications with market approval, while aiming to improve cognitive and functional outcomes of a patient with dementia, are associated with reported body weight or body mass index loss. This review presents evidence in the published literature on body weight loss in dementia, describes selected theories behind body weight loss, evaluates the potential impact of approved dementia pharmacotherapies on body weight, considers the potential role for medical foods, understands the potential influence of treatments for neuropsychiatric symptoms and signs, and finally, summarizes this important area.

National Category
Clinical Medicine Health Sciences
Identifiers
urn:nbn:se:his:diva-13791 (URN)10.1007/s40266-017-0462-x (DOI)000401319400002 ()28478593 (PubMedID)2-s2.0-85027878619 (Scopus ID)
Available from: 2017-06-20 Created: 2017-06-20 Last updated: 2017-11-27Bibliographically approved
Organisations

Search in DiVA

Show all publications