Open this publication in new window or tab >>Aging Research Centre, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Solna, Stockholm, Sweden ; Stockholm Gerontology Research Center, Sweden.
Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.
Clinicum, Faculty of Medicine, University of Helsinki, Finland ; Finnish Institute of Occupational Health, Helsinki, Finland ; UCL Faculty of Brain Sciences, University College London, United Kingdom.
Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland.
Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland ; Stockholm Gerontology Research Center, Sweden.
Department of Public Health, University of Turku, Turku University Hospital, Finland ; School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada.
University of Skövde, School of Health Sciences. University of Skövde, Digital Health Research (DHEAR). Department of Public Health, University of Turku and Turku University Hospital, Finland.
Department of Public Health, University of Turku, Turku University Hospital, Finland ; Centre for Population Health Research, University of Turku, Turku University Hospital, Finland.
Department of Public Health, University of Turku, Turku University Hospital, Finland ; Centre for Population Health Research, University of Turku, Turku University Hospital, Finland ; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Finland.
Department of Public Health, University of Turku, Turku University Hospital, Finland ; Centre for Population Health Research, University of Turku, Turku University Hospital, Finland ; Research Services, Turku University Hospital, University of Turku, Finland.
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2024 (English)In: Age and Ageing, ISSN 0002-0729, E-ISSN 1468-2834, Vol. 53, no 7, article id afae141Article in journal (Refereed) Published
Abstract [en]
Background: Stimulating activities are associated with a decreased risk of dementia. However, the extent to which this reflects a protective effect of activity or non-participation resulting from dementia is debated. We investigated the association of stimulating leisure-time activity in late adulthood with the risk of dementia across up to two decades' follow-up. Methods: We used data from five prospective cohort studies from Finland and Sweden. Mental, social, outdoor, consumptive and physical leisure-time activities were self-reported. Incident dementia was ascertained from clinical diagnoses or healthcare and death registers. Cox regression was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). Results: Of the 33 263 dementia-free individuals aged ≥50 years at baseline, 1408 had dementia during a mean follow-up of 7.0 years. Active participation in mental (HR: 0.52, 95% CI: 0.41 to 0.65), social (HR: 0.56 95% CI: 0.46 to 0.72), outdoor (HR: 0.70, 95% CI: 0.58 to 0.85), consumptive (HR: 0.67, 95% CI: 0.53 to 0.94) and physical (HR: 0.62, 95% CI: 0.51 to 0.75) activity, as well as variety (HR: 0.54, 95% CI: 0.43 to 0.68) and the overall frequency of activity (HR: 0.41, 95% CI: 0.34 to 0.49) were associated with a reduced risk of dementia in <10 years' follow-up. In ≥10 years' follow-up all associations attenuated toward the null. Conclusion: Stimulating leisure-time activities are associated with a reduced risk of dementia in short-term but not long-term follow-up. These findings may reflect a reduction in leisure-time activity following preclinical dementia or dilution of the association over time.
Place, publisher, year, edition, pages
Oxford University Press, 2024
Keywords
activity, cognitive, dementia, meta-analysis, older people, prospective study, Aged, Female, Finland, Humans, Incidence, Leisure Activities, Male, Middle Aged, Prospective Studies, Protective Factors, Risk Assessment, Risk Factors, Sweden, Time Factors, adult, animal hunting, Article, cognition, cohort analysis, depression, exercise, follow up, gardening, human, human experiment, immobility, jogging, leisure, physical activity, reading, self report, sensitivity analysis, social support, stimulating leisure-time activity, walking, clinical trial, diagnosis, epidemiology, multicenter study, prevention and control, protection, psychology, risk factor, time factor
National Category
Gerontology, specialising in Medical and Health Sciences Geriatrics Public Health, Global Health, Social Medicine and Epidemiology
Research subject
Research on Citizen Centered Health, University of Skövde (Reacch US)
Identifiers
urn:nbn:se:his:diva-24403 (URN)10.1093/ageing/afae141 (DOI)001267491700001 ()39003234 (PubMedID)2-s2.0-85198695591 (Scopus ID)
Funder
Swedish Research Council, 2011-6,243Swedish Research Council, 2017-06088Forte, Swedish Research Council for Health, Working Life and Welfare, 2016-07175Wellcome trust, 221854/Z/20/ZNIH (National Institutes of Health), R01AG056477NIH (National Institutes of Health), R01AG062553Academy of Finland, 321409Academy of Finland, 329240
Note
CC BY 4.0 Deed
© 2024 The Author(s)
Correspondence Address: K. Heikkilä; Department of Public Health, University of Turku, Turku, Kiinamyllynkatu 10, 20520, Finland; email: katriina.heikkila@utu.fi; CODEN: AANGA
SNAC-K receives financial support from the Swedish Research Council (Vetenskapsrådet, 2011-6,243; 2017-06088), the Swedish Research Council for Health, Working Life and Welfare (FORTE, 2016-07175), and is supported by the Swedish Ministry of Health and Social Affairs and the participating County Councils and Municipalities. MK was supported by Wellcome Trust (221854/Z/20/Z), UK Medical Research Council (S011676, Y014154), US National Institute on Aging (NIH, R01AG056477, R01AG062553), and Research Council Finland (350426). JV was supported by the Academy of Finland (321409 and 329240). S Stenholm was supported by Research Council Finland (332030), Juho Vainio Foundation and Signe and Ane Gyllenberg Foundation. S Stenlund was supported by Signe and Ane Gyllenberg Foundation. The authors thank the research teams that collected, linked and curated data and especially all the individuals who participated in the longitudinal cohort studies.
2024-07-252024-07-252024-10-09Bibliographically approved