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Dönnes, Pierre
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Feldhahn, M., Dönnes, P., Schubert, B., Schilbach, K., Rammensee, H.-G. & Kohlbacher, O. (2012). miHA-Match: Computational detection of tissue-specific minor histocompatibility antigens. JIM - Journal of Immunological Methods, 386(1-2), 94-100
Open this publication in new window or tab >>miHA-Match: Computational detection of tissue-specific minor histocompatibility antigens
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2012 (English)In: JIM - Journal of Immunological Methods, ISSN 0022-1759, E-ISSN 1872-7905, Vol. 386, no 1-2, p. 94-100Article in journal (Refereed) Published
Abstract [en]

Allogenic stem cell transplantation has shown considerable success in a number of hematological malignancies, in particular in leukemia. The beneficial effect is mediated by donor T cells recognizing patient-specific HLA-binding peptides. These peptides are called minor histocompatibility antigens (miHAs) and are typically caused by single nucleotide polymorphisms. Tissue-specific miHAs have successfully been used in anti-tumor therapy without causing unspecific graft-versus-host reactions. However, only a small number of miHAs have been identified to date, limiting the clinical use.

Here we present an immunoinformatics pipeline for the identification of miHAs. The pipeline can be applied to large-scale miHA screening, for example, in the development of diagnostic tests. Another interesting application is the design of personalized miHA-based cancer therapies based on patient-donor pair-specific miHAs detected by this pipeline. The suggested method covers various aspects of genetic variant detection, effects of alternative transcripts, and HLA-peptide binding. A comparison of our computational pipeline and experimentally derived datasets shows excellent agreement and coverage of the computationally predicted miHAs.

Place, publisher, year, edition, pages
Elsevier, 2012
Keywords
Minor histocompatibility antigens, Immunoinformatics, Transplantation
National Category
Bioinformatics and Systems Biology
Research subject
Natural sciences
Identifiers
urn:nbn:se:his:diva-7141 (URN)10.1016/j.jim.2012.09.004 (DOI)000311132800012 ()22985828 (PubMedID)2-s2.0-84867445887 (Scopus ID)
Available from: 2013-02-13 Created: 2013-02-07 Last updated: 2017-12-06Bibliographically approved
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