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Uvnäs-Moberg, KerstinORCID iD iconorcid.org/0000-0003-4902-839X
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Publications (10 of 13) Show all publications
Uvnäs-Moberg, K., Ekström-Bergström, A., Berg, M., Buckley, S., Pajalic, Z., Hadjigeorgiou, E., . . . Dencker, A. (2019). Maternal plasma levels of oxytocin during physiological childbirth: A systematic review with implications for uterine contractions and central actions of oxytocin. BMC Pregnancy and Childbirth, 19(1), Article ID 285.
Open this publication in new window or tab >>Maternal plasma levels of oxytocin during physiological childbirth: A systematic review with implications for uterine contractions and central actions of oxytocin
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2019 (English)In: BMC Pregnancy and Childbirth, ISSN 1471-2393, E-ISSN 1471-2393, Vol. 19, no 1, article id 285Article, review/survey (Refereed) Published
Abstract [en]

Background: Oxytocin is a key hormone in childbirth, and synthetic oxytocin is widely administered to induce or speed labour. Due to lack of synthetized knowledge, we conducted a systematic review of maternal plasma levels of oxytocin during physiological childbirth, and in response to infusions of synthetic oxytocin, if reported in the included studies. Methods: An a priori protocol was designed and a systematic search was conducted in PubMed, CINAHL, and PsycINFO in October 2015. Search hits were screened on title and abstract after duplicates were removed (n = 4039), 69 articles were examined in full-text and 20 papers met inclusion criteria. As the articles differed in design and methodology used for analysis of oxytocin levels, a narrative synthesis was created and the material was categorised according to effects. Results: Basal levels of oxytocin increased 3-4-fold during pregnancy. Pulses of oxytocin occurred with increasing frequency, duration, and amplitude, from late pregnancy through labour, reaching a maximum of 3 pulses/10 min towards the end of labour. There was a maximal 3- to 4-fold rise in oxytocin at birth. Oxytocin pulses also occurred in the third stage of labour associated with placental expulsion. Oxytocin peaks during labour did not correlate in time with individual uterine contractions, suggesting additional mechanisms in the control of contractions. Oxytocin levels were also raised in the cerebrospinal fluid during labour, indicating that oxytocin is released into the brain, as well as into the circulation. Oxytocin released into the brain induces beneficial adaptive effects during birth and postpartum. Oxytocin levels following infusion of synthetic oxytocin up to 10 mU/min were similar to oxytocin levels in physiological labour. Oxytocin levels doubled in response to doubling of the rate of infusion of synthetic oxytocin. Conclusions: Plasma oxytocin levels increase gradually during pregnancy, and during the first and second stages of labour, with increasing size and frequency of pulses of oxytocin. A large pulse of oxytocin occurs with birth. Oxytocin in the circulation stimulates uterine contractions and oxytocin released within the brain influences maternal physiology and behaviour during birth. Oxytocin given as an infusion does not cross into the mother's brain because of the blood brain barrier and does not influence brain function in the same way as oxytocin during normal labour does. 

Place, publisher, year, edition, pages
BioMed Central, 2019
Keywords
Birth, Central effects, Infusion of synthetic oxytocin, Neurobiology, Oxytocin, Physiological labour, Plasma levels, Pregnancy, Uterine contractions
National Category
Obstetrics, Gynecology and Reproductive Medicine
Research subject
Woman, Child and Family (WomFam)
Identifiers
urn:nbn:se:his:diva-17578 (URN)10.1186/s12884-019-2365-9 (DOI)000480573400001 ()31399062 (PubMedID)2-s2.0-85070456069 (Scopus ID)
Available from: 2019-08-23 Created: 2019-08-23 Last updated: 2019-08-29Bibliographically approved
Handlin, L., Nilsson, A., Lidfors, L., Petersson, M. & Uvnäs-Moberg, K. (2018). The Effects of a Therapy Dog on the Blood Pressure and Heart Rate of Older Residents in a Nursing Home. Anthrozoos, 31(5), 567-576
Open this publication in new window or tab >>The Effects of a Therapy Dog on the Blood Pressure and Heart Rate of Older Residents in a Nursing Home
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2018 (English)In: Anthrozoos, ISSN 0892-7936, E-ISSN 1753-0377, Vol. 31, no 5, p. 567-576Article in journal (Refereed) Published
Abstract [en]

The aim of the present project was to investigate whether repeated visits by a therapy dog to nursing homes might affect the older residents’ systolic blood pressure and heart rate. A secondary aim was to investigate and compare effects (differences in responses) in older people with high and normal systolic blood pressure. The project consisted of two consecutive studies; the dog study (two researchers and a therapy dog with a handler visited the residents at three nursing homes, n = 13), and the controlstudy (the two researchers alone visited the residents at three different nursinghomes, n = 13). The studies were divided into three periods; period 1(weeks 1–2), period 2 (weeks 3–4), and period 3 (weeks 5–6) and included two visits per week. The dog and her handler visited during periods 2 and 3 in the dog study. Participants’ heart rate and blood pressure were measured at 0 and 20 minutes at each visit. The data were analyzed using Friedman’s twowayanalysis of Variance by Rank with post-hoc analysis using Wilcoxonsigned-rank tests with a Bonferroni correction, and also with the mann-Whitney U test for independent samples. In the dog study, participants’ heartrate decreased significantly (p = 0.006) from period 1 to period 3. Participants with an initial systolic blood pressure ≥ 130 mmhg had a significant decreasein both systolic blood pressure (p = 0.009) and heart rate (p = 0.009). In the control study, participants’ heart rate and systolic blood pressure did not change significantly. the participants in the dog study had a significantly lower systolic blood pressure during period 3 (p = 0.016) compared with those in the control study. In conclusion, repeated visits by a therapy dog–handler team decreased the older adults’ heart rate, and for those with high initial systolic blood pressure, blood pressure also decreased. In addition, systolic blood pressure decreased significantly in the dog group when compared with the control group.

Keywords
heart rate, human–animal interaction, older adults, systolic blood pressure, therapy dog
National Category
Nursing
Research subject
Translational Medicine TRIM
Identifiers
urn:nbn:se:his:diva-16223 (URN)10.1080/08927936.2018.1505268 (DOI)000445072300004 ()2-s2.0-85053562177 (Scopus ID)
Available from: 2018-09-20 Created: 2018-09-20 Last updated: 2018-12-03Bibliographically approved
Petersson, M., Uvnäs-Moberg, K., Nilsson, A., Gustafsson, L.-L., Hydbring-Sandberg, E. & Handlin, L. (2017). Oxytocin and Cortisol Levels in Dog Owners and Their Dogs Are Associated with Behavioral Patterns: An Exploratory Study. Frontiers in Psychology, 8, Article ID 1796.
Open this publication in new window or tab >>Oxytocin and Cortisol Levels in Dog Owners and Their Dogs Are Associated with Behavioral Patterns: An Exploratory Study
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2017 (English)In: Frontiers in Psychology, ISSN 1664-1078, E-ISSN 1664-1078, Vol. 8, article id 1796Article in journal (Refereed) Published
Abstract [en]

We have previously shown that dog–owner interaction results in increasing oxytocin levels in owners and dogs, decreasing cortisol levels in owners but increasing cortisol levels in dogs. The present study aimed to further investigate whether oxytocin and cortisol levels in the previously tested owners and dogs were associated with their behaviors during the interaction experiment. Ten female volunteer dog–owners and their male Labrador dogs participated in a 60 min interaction experiment with interaction taking place during 0–3 min and blood samples for analysis of oxytocin and cortisol were collected at 0, 1, 3, 5, 15, 30, and 60 min. The entire experiment was videotaped and the following variables were noted; the different types (stroking, scratching, patting and activating touch, i.e., scratching and patting combined) as well as the frequency of touch applied by the owner, the number of times the owner touched her dog, the dog’s positions and time spent in each position. Correlations were analyzed between the behavioral variables and basal oxytocin levels, maximum oxytocin levels, delta oxytocin levels, basal cortisol levels and cortisol levels at 15 min. Owners with low oxytocin levels before and during the interaction touched their dogs more frequently (0 min: Rs = −0.683, p = 0.042; oxytocin maximum: Rs = −0.783, p = 0.013). The lower the dogs’ oxytocin levels during the interaction, the more stroking they received (Rs = −0.717, p = 0.041). The more frequently activating touch was applied by the owner, the higher the dogs’ cortisol levels became (15 min: Rs = 0.661, p = 0.038). The higher the owners’ maximum oxytocin level the fewer position changes the dogs made (Rs = −0.817, p = 0.007) and the shorter time they spent sitting (Rs = −0.786, p = 0.036), whereas the higher the owners’ basal cortisol levels, the longer time the dogs spent standing (0 min: Rs = 0.683, p = 0.041). In conclusion, oxytocin and cortisol levels, both in dogs and in their owners, are associated with the way the owners interact with their dogs and also with behaviors caused by the interaction.

Place, publisher, year, edition, pages
Frontiers Media S.A., 2017
Keywords
oxytocin, cortisol, dog–human interaction, behavior
National Category
Neurosciences
Research subject
Translational Medicine TRIM
Identifiers
urn:nbn:se:his:diva-14233 (URN)10.3389/fpsyg.2017.01796 (DOI)000412875600001 ()2-s2.0-85032180504 (Scopus ID)
Funder
Swedish Research Council Formas, 221-2003-1098
Available from: 2017-10-16 Created: 2017-10-16 Last updated: 2018-02-16Bibliographically approved
Uvnäs-Moberg, K., Handlin, L. & Petersson, M. (2015). Self-soothing behaviors with particular reference to oxytocin release induced by non-noxious sensory stimulation. Frontiers in Psychology, 5, Article ID 1529.
Open this publication in new window or tab >>Self-soothing behaviors with particular reference to oxytocin release induced by non-noxious sensory stimulation
2015 (English)In: Frontiers in Psychology, ISSN 1664-1078, E-ISSN 1664-1078, Vol. 5, article id 1529Article, review/survey (Refereed) Published
Place, publisher, year, edition, pages
Frontiers Media S.A., 2015
Keywords
oxytocin, non-noxious sensory stimulation, afferent nerves, anti-stress effects
National Category
Other Medical Sciences
Research subject
Medical sciences; Woman, Child and Family (WomFam)
Identifiers
urn:nbn:se:his:diva-10524 (URN)10.3389/fpsyg.2014.01529 (DOI)000348135400001 ()25628581 (PubMedID)2-s2.0-84926617655 (Scopus ID)
Available from: 2015-01-13 Created: 2015-01-13 Last updated: 2019-08-29Bibliographically approved
Takahashi, Y., Jonas, W., Ransjo-Arvidson, A.-B., Lidfors, L., Uvnäs Moberg, K. & Nissen, E. (2015). Weight loss and low age are associated with intensity of rooting behaviours in newborn infants. Acta Paediatrica, 104(10), 1018-1023
Open this publication in new window or tab >>Weight loss and low age are associated with intensity of rooting behaviours in newborn infants
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2015 (English)In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 104, no 10, p. 1018-1023Article in journal (Refereed) Published
Abstract [en]

Aim: Little is known about the developing breastfeeding behaviour of newborn infants. This study describes infants' prebreastfeeding behaviour during the second day of life and explores possible associations with infant characteristics. Methods: We studied 13 mothers and healthy full-term infants after normal births. At 2448 hours of life, the newborns were placed in skin-to-skin contact with their mothers for breastfeeding and were video-filmed. The order, frequency and duration of predefined infant prefeeding behaviours and suckling were coded and analysed using computer-based video software. Results: Prefeeding behaviours occurred in the following order: rooting, hand to mouth movements, licking of the nipple and hand to breast to mouth movements. The infants started to suckle at a median of one to two minutes. Rooting was the most common behaviour, observed in 12 infants. The duration of rooting movements during the last minute before breastfeeding was inversely related to neonatal age (p = 0.001) and positively related to neonatal weight loss (p = 0.02) after birth. Conclusion: Infants exhibited a distinct sequence of prefeeding behaviours during the second day of life, and our findings suggest that rooting movements were governed by mechanisms involved in the regulation of food intake and weight gain.

Place, publisher, year, edition, pages
John Wiley & Sons, 2015
Keywords
Breastfeeding behaviour, Infant age, Infant weight loss, Prefeeding behaviour, Rooting behaviour
National Category
Nutrition and Dietetics Pediatrics
Research subject
Woman, Child and Family (WomFam)
Identifiers
urn:nbn:se:his:diva-13584 (URN)10.1111/apa.13077 (DOI)000362512100020 ()26073678 (PubMedID)2-s2.0-84976542346 (Scopus ID)
Available from: 2017-05-23 Created: 2017-05-23 Last updated: 2019-02-19Bibliographically approved
Rehn, T., Handlin, L., Uvnäs-Moberg, K. & Keeling, L. J. (2014). Dogs' endocrine and behavioural responses at reunion are affected by how the human initiates contact. Physiology and Behavior, 124, 45-53
Open this publication in new window or tab >>Dogs' endocrine and behavioural responses at reunion are affected by how the human initiates contact
2014 (English)In: Physiology and Behavior, ISSN 0031-9384, E-ISSN 1873-507X, Vol. 124, p. 45-53Article in journal (Refereed) Published
Place, publisher, year, edition, pages
Elsevier, 2014
National Category
Natural Sciences Behavioral Sciences Biology Physiology
Research subject
Natural sciences
Identifiers
urn:nbn:se:his:diva-9964 (URN)10.1016/j.physbeh.2013.10.009 (DOI)000331482200007 ()24513557 (PubMedID)2-s2.0-84887736438 (Scopus ID)
Available from: 2014-09-17 Created: 2014-09-17 Last updated: 2018-01-11Bibliographically approved
Handlin, L., Nilsson, A., Ejdebäck, M., Hydbring-Sandberg, E. & Uvnäs-Moberg, K. (2012). Associations between the Psychological Characteristics of the Human-Dog Relationship and Oxytocin and Cortisol Levels. Anthrozoos, 25(2), 215-228
Open this publication in new window or tab >>Associations between the Psychological Characteristics of the Human-Dog Relationship and Oxytocin and Cortisol Levels
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2012 (English)In: Anthrozoos, ISSN 0892-7936, E-ISSN 1753-0377, Vol. 25, no 2, p. 215-228Article in journal (Refereed) Published
Abstract [en]

The aim of the present study was to explore possible correlations between dog owners' relationships with their dogs, as measured with the Monash Dog Owner Relationship Scale (MDORS), and oxytocin and cortisol levels in both the owners and their dogs. Ten female owners of male Labrador Retrievers completed the MDORS. The scores obtained from the single items, subscales, and total score of the MDORS were calculated. Ten blood samples were collected from each dog owner and her dog during a 60-minute interaction. Blood samples were analyzed for oxytocin and cortisol by Enzyme Immuno Assay (EIA) and mean values of oxytocin and cortisol were calculated in both owners and dogs. The MDORS scores obtained were correlated with basal and mean oxytocin and cortisol levels. The correlation analysis revealed some relationships between the scores of items in the MDORS that reflect the character of the dog-owner-relationship and the owners' hormone levels. For example, higher oxytocin levels in the owners were associated with greater frequency in kissing their dogs (rs = 0.864, p = 0.001). Lower cortisol levels in the owners were associated with their perception that it will be more traumatic when their dog dies (rs = -0.730, p = 0.025). The correlation analysis also revealed some relationships between the scores of items in the MDORS and the dogs' hormone levels. For example, greater frequency in owners kissing their dogs was associated with higher oxytocin levels in the dogs (rs = 0.753, p = 0.029). Six items in the subscale Perceived Costs, as well as the subscale itself, correlated significantly with the dogs' oxytocin levels (rs = 0.820, p = 0.007), that is, the lower the perceived cost, the higher the dogs' oxytocin levels. In addition, significant correlations between the oxytocin levels of the owners and the dogs were demonstrated. Possible mechanisms behind these correlations are discussed. In conclusion, the scores of some items and the subscales of the MDORS correlated with oxytocin, and to a lesser extent cortisol, levels in both the owners and dogs.

Place, publisher, year, edition, pages
Berg Publishers, 2012
Keywords
cortisol, dog, dog owner, MDORS, oxytocin
National Category
Natural Sciences
Research subject
Natural sciences
Identifiers
urn:nbn:se:his:diva-5929 (URN)10.2752/175303712X13316289505468 (DOI)000304287700007 ()2-s2.0-84859540616 (Scopus ID)
Available from: 2012-06-05 Created: 2012-06-05 Last updated: 2017-12-07Bibliographically approved
Handlin, L., Jonas, W., Ransjö-Arvidson, A.-B., Petersson, M., Uvnäs-Moberg, K. & Nissen, E. (2012). Influence of Common Birth Interventions on Maternal Blood Pressure Patterns During Breastfeeding 2 Days After Birth. Breastfeeding Medicine, 7(2), 93-99
Open this publication in new window or tab >>Influence of Common Birth Interventions on Maternal Blood Pressure Patterns During Breastfeeding 2 Days After Birth
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2012 (English)In: Breastfeeding Medicine, ISSN 1556-8253, Vol. 7, no 2, p. 93-99Article in journal (Refereed) Published
Abstract [en]

Objective: This study investigated possible influences of medical interventions during labor on maternal blood pressure during a breastfeed 2 days postpartum.

Subjects and Methods: Sixty-six primiparae with normal deliveries were consecutively recruited. Blood pressure was measured at –5, 10, 30, and 60 minutes during a morning breastfeed 2 days postpartum. Five treatment groups were formed based on the medical interventions received during labor: Non-medicated mothers (Control group, n=21); mothers receiving epidural analgesia (EDA) with oxytocin (OT) stimulation (EDAOT group, n=14); mothers receiving EDA without OT stimulation (EDAnon-OT group, n=7); mothers receiving OT stimulation only (OT intravenously [iv] group, n=9); and mothers receiving 10 IU of OT intramuscularly (im) only (OT im group, n=15).

Results: Baseline diastolic, but not systolic, blood pressure differed between the groups as displayed by significantly lower diastolic blood pressure in the EDAnon-OT group compared with the Control group, the OT iv group, and the EDAOT group (p=0.045, p=0.041, and p=0.024, respectively). Both systolic and diastolic blood pressure fell significantly during the breastfeeding session in the Control group (p=0.001 and p=0.004, respectively), the OT im group (p=0.006 and p=0.001, respectively), and the EDAOT group (p=0.028 and p=0.002, respectively), and the fall in diastolic blood pressure tended to be significant in the OT iv group (p=0.050). The duration of skin-to-skin contact before breastfeeding correlated positively with the decrease in systolic blood pressure in the OT im group (Rs=0.540, p=0.046).

Conclusion: Administration of EDA during labor lowers baseline diastolic blood pressure and abolishes the fall in blood pressure in response to a breastfeed 2 days after birth.

Place, publisher, year, edition, pages
Mary Ann Liebert, 2012
National Category
Natural Sciences
Research subject
Natural sciences
Identifiers
urn:nbn:se:his:diva-5933 (URN)10.1089/bfm.2010.0099 (DOI)000302777000005 ()22313391 (PubMedID)2-s2.0-84859569252 (Scopus ID)
Available from: 2012-06-05 Created: 2012-06-05 Last updated: 2018-05-03Bibliographically approved
Uvnäs-Moberg, K., Handlin, L. & Petersson, M. (2011). Promises and pitfalls of hormone research in human-animal interaction (1ed.). In: Peggy McCardle, Sandra McCune, James A. Griffin, Valerie Maholmes (Ed.), How Animals Affect Us: Examining the Influence of Human-Animal Interaction on Child Development and Human Health. American Psychological Association (APA)
Open this publication in new window or tab >>Promises and pitfalls of hormone research in human-animal interaction
2011 (English)In: How Animals Affect Us: Examining the Influence of Human-Animal Interaction on Child Development and Human Health / [ed] Peggy McCardle, Sandra McCune, James A. Griffin, Valerie Maholmes, American Psychological Association (APA), 2011, 1Chapter in book (Other academic)
Place, publisher, year, edition, pages
American Psychological Association (APA), 2011 Edition: 1
National Category
Natural Sciences
Research subject
Natural sciences
Identifiers
urn:nbn:se:his:diva-4703 (URN)978-1-4338-0865-4 (ISBN)1-4338-0865-X (ISBN)
Available from: 2011-02-01 Created: 2011-02-01 Last updated: 2017-11-27Bibliographically approved
Handlin, L., Hydbring-Sandberg, E., Nilsson, A., Ejdebäck, M., Jansson, A. & Uvnäs-Moberg, K. (2011). Short-Term Interaction between Dogs and Their Owners: Effects on Oxytocin, Cortisol, Insulin and Heart Rate-An Exploratory Study. Anthrozoos, 24(3), 301-315
Open this publication in new window or tab >>Short-Term Interaction between Dogs and Their Owners: Effects on Oxytocin, Cortisol, Insulin and Heart Rate-An Exploratory Study
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2011 (English)In: Anthrozoos, ISSN 0892-7936, E-ISSN 1753-0377, Vol. 24, no 3, p. 301-315Article in journal (Refereed) Published
Abstract [en]

The aim of this exploratory study was to determine heart rate and the levels of oxytocin, cortisol, and insulin in dogs and their owners in response to a short-term interaction. In addition, the dogs' behavior was studied. The owners' responses were compared with those obtained from a control group. Ten female volunteers and their own male Labrador dogs participated in an experiment during which the owner stroked, petted, and talked with her dog during the first 3 minutes. Blood samples were collected from both dog and owner before (0) and at 1, 3, 5, 15, 30, and 60 minutes after the start of the interaction. Blood samples were analyzed by EIA. Heart rate was monitored telemetrically. The data were analyzed using linear mixed models and paired t-tests. The dogs' oxytocin levels were significantly increased 3 minutes after the start of the interaction (p = 0.027). Cortisol levels were significantly increased after 15 and 30 minutes (p = 0.004 and p = 0.022, respectively), and heart rate was significantly decreased after 55 minutes (p = 0.008). The dogs displayed normal behaviors during the experiment. The owners' oxylocin levels peaked between 1 and 5 minutes after interaction (p = 0.026). No such effect was seen in the controls. Cortisol levels displayed a significant decrease at 15 or 30 minutes in both owners and controls, and insulin levels did so at 60 minutes (p = 0.030, p = 0.002 and p = 0.002, p < 0.0001, respectively). Heart rate decreased significantly in the owners at 55 and 60 minutes (p = 0.0008) but not in the controls. In conclusion, short-term sensory interaction between dogs and their owners influences hormonal levels and heart rate. However, further studies need to be performed in order to better understand the effects of interaction between dogs and their owners.

Place, publisher, year, edition, pages
Berg Publishers, 2011
Keywords
cortisol, heart rate, human dog interaction, insulin, oxytocin
National Category
Natural Sciences
Research subject
Natural sciences
Identifiers
urn:nbn:se:his:diva-5520 (URN)10.2752/175303711X13045914865385 (DOI)000295154400006 ()2-s2.0-79960721263 (Scopus ID)
Available from: 2012-03-22 Created: 2012-03-01 Last updated: 2017-12-07Bibliographically approved
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ORCID iD: ORCID iD iconorcid.org/0000-0003-4902-839X

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