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Kenne Sarenmalm, ElisabethORCID iD iconorcid.org/0000-0001-9559-0952
Publikationer (7 of 7) Visa alla publikationer
Kenne Sarenmalm, E., Mårtensson, L. B., Andersson, B. A., Karlsson, P. & Bergh, I. (2017). Mindfulness and its efficacy for psychological and biological responses in women with breast cancer. Cancer Medicine, 6(5), 1108-1122
Öppna denna publikation i ny flik eller fönster >>Mindfulness and its efficacy for psychological and biological responses in women with breast cancer
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2017 (Engelska)Ingår i: Cancer Medicine, ISSN 2045-7634, E-ISSN 2045-7634, Vol. 6, nr 5, s. 1108-1122Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Many breast cancer survivors have to deal with a variety of psychological andphysiological sequelae including impaired immune responses. The primary purposeof this randomized controlled trial was to determine the efficacy of amindfulness-basedstress reduction (MBSR) intervention for mood disorders inwomen with breast cancer. Secondary outcomes were symptom experience, healthstatus, coping capacity, mindfulness, posttraumatic growth, and immune status.This RTC assigned 166 women with breast cancer to one of three groups: MBSR(8 weekly group sessions of MBSR), active controls (self-instructingMBSR) andnon-MBSR.The primary outcome measure was the Hospital Anxiety and DepressionScale. Secondary outcome measures were: Memorial Symptom AssessmentScale, SF-36,Sense of Coherence, Five Facets of Mindfulness Questionnaire,and Posttraumatic Growth Index. Blood samples were analyzed using flow cytometryfor NK-cellactivity (FANKIA) and lymphocyte phenotyping; concentrationsof cytokines were determined in sera using commercial high sensitivityIL-6and IL-8ELISA (enzyme-linkedimmunosorbent assay) kits. Results provideevidence for beneficial effects of MBSR on psychological and biological responses.Women in the MBSR group experienced significant improvements in depressionscores, with a mean pre-MBSRHAD-scoreof 4.3 and post-MBSRscore of 3.3(P = 0.001), and compared to non-MBSR(P = 0.015). Significant improvementson scores for distress, symptom burden, and mental health were also observed.Furthermore, MBSR facilitated coping capacity as well as mindfulness and posttraumaticgrowth. Significant benefits in immune response within the MBSRgroup and between groups were observed. MBSR have potential for alleviatingdepression, symptom experience, and for enhancing coping capacity, mindfulnessand posttraumatic growth, which may improve breast cancer survivorship.MBSR also led to beneficial effect on immune function; the clinical implicationsof this finding merit further research.

Ort, förlag, år, upplaga, sidor
John Wiley & Sons Ltd., 2017
Nyckelord
Breast cancer, immune response, mindfulness-based stress reduction, randomized clinical trial
Nationell ämneskategori
Omvårdnad
Forskningsämne
Kvinna, barn och familj (WomFam)
Identifikatorer
urn:nbn:se:his:diva-13514 (URN)10.1002/cam4.1052 (DOI)000401330300023 ()28421677 (PubMedID)2-s2.0-85018595351 (Scopus ID)
Tillgänglig från: 2017-04-20 Skapad: 2017-04-20 Senast uppdaterad: 2019-11-25
Browall, M., Kenne Sarenmalm, E., Persson, L.-O., Wengström, Y. & Gaston-Johansson, F. (2016). Patient-reported stressful events and coping strategies in post-menopausal women with breast cancer. European Journal of Cancer Care, 25(2), 324-333
Öppna denna publikation i ny flik eller fönster >>Patient-reported stressful events and coping strategies in post-menopausal women with breast cancer
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2016 (Engelska)Ingår i: European Journal of Cancer Care, ISSN 0961-5423, E-ISSN 1365-2354, Vol. 25, nr 2, s. 324-333Artikel i tidskrift (Refereegranskat) Published
Ort, förlag, år, upplaga, sidor
John Wiley & Sons, 2016
Nyckelord
breast cancer, coping strategies, diary, level of bother, post-menopausal, stressful events
Nationell ämneskategori
Omvårdnad
Forskningsämne
Medicin
Identifikatorer
urn:nbn:se:his:diva-10730 (URN)10.1111/ecc.12294 (DOI)000371475800016 ()25690645 (PubMedID)2-s2.0-84958852754 (Scopus ID)
Tillgänglig från: 2015-03-10 Skapad: 2015-03-10 Senast uppdaterad: 2017-12-04Bibliografiskt granskad
Kenne Sarenmalm, E., Browall, M. & Gaston-Johansson, F. (2014). Symptom Burden Clusters: A Challenge for Targeted Symptom Management. A Longitudinal Study Examining Symptom Burden Clusters in Breast Cancer. Journal of Pain and Symptom Management, 47(4), 731-741
Öppna denna publikation i ny flik eller fönster >>Symptom Burden Clusters: A Challenge for Targeted Symptom Management. A Longitudinal Study Examining Symptom Burden Clusters in Breast Cancer
2014 (Engelska)Ingår i: Journal of Pain and Symptom Management, ISSN 0885-3924, E-ISSN 1873-6513, Vol. 47, nr 4, s. 731-741Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Context: Although there has been a growing interest in cancer symptom clusters, less is known about symptom burden clusters. Objectives: To explore clusters of burdensome symptoms over time, the impact on health status and quality of life, and coping capacity in patients with breast cancer. Methods: In this longitudinal study, a sample of 206 patients completed the Memorial Symptom Assessment Scale, the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire, and the Sense of Coherence scale, at diagnosis of primary or recurrent breast cancer, and at one-, three-, and six-month follow-ups. Results: Three clusters of burdensome symptoms were identified: emotional symptom burden, gastrointestinal symptom burden, and unwellness symptom burden. Most burdensome were emotional symptoms, with worrying, feeling sad, and feeling nervous as the core or defining symptoms. Over time, additional symptoms escalated the emotional symptom burden. The gastrointestinal symptom burden, with "change in the way food tastes" as a core symptom, was more often associated with chemotherapy. Less stable over time, the unwellness symptom burden could be interpreted as short- and long-term side effects of hormonal therapy. Of these clusters, only the emotional symptom burden cluster significantly diminished health status and quality of life. Patients reporting lower coping capacity experienced higher levels of symptom burden. Conclusion: This study provides insights into symptom burden clusters over time. A challenging approach toward symptom management in clinical oncology is to target the burden of a symptom cluster and to recognize the need for individually designed interventions to ameliorate symptom burden in cancer patients. © 2013 U.S. Cancer Pain Relief Committee.

Ort, förlag, år, upplaga, sidor
Elsevier, 2014
Nyckelord
Breast cancer, health status, quality of life, sense of coherence, symptom burden, symptom burden clusters
Nationell ämneskategori
Hälsovetenskaper
Forskningsämne
Medicin
Identifikatorer
urn:nbn:se:his:diva-8614 (URN)10.1016/j.jpainsymman.2013.05.012 (DOI)000334588100012 ()23916827 (PubMedID)2-s2.0-84898835050 (Scopus ID)
Tillgänglig från: 2013-11-04 Skapad: 2013-11-04 Senast uppdaterad: 2017-12-06Bibliografiskt granskad
Kenne Sarenmalm, E., Mårtensson, L. B., Holmberg, S. B., Andersson, B. A., Odén, A. & Bergh, I. (2013). Mindfulness based stress reduction study design of a longitudinal randomized controlled complementary intervention in women with breast cancer. BMC Complementary and Alternative Medicine, 13, Article ID 248.
Öppna denna publikation i ny flik eller fönster >>Mindfulness based stress reduction study design of a longitudinal randomized controlled complementary intervention in women with breast cancer
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2013 (Engelska)Ingår i: BMC Complementary and Alternative Medicine, ISSN 1472-6882, E-ISSN 1472-6882, Vol. 13, artikel-id 248Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background: The stress of a breast cancer diagnosis and its treatment can produce a variety of psychosocial sequelae including impaired immune responses. Mindfulness Based Stress Reduction (MBSR) is a structured complementary program that incorporates meditation, yoga and mind-body exercises. Despite promising empirical evidence for the efficacy of MBSR, there is a need for randomized controlled trials (RCT). There is also a need for RCTs investigating the efficacy of psychosocial interventions on mood disorder and immune response in women with breast cancer. Therefore, the overall aim is to determine the efficacy of a Mindfulness Based Stress Reduction (MBSR) intervention on well-being and immune response in women with breast cancer.Methods and design: In this RCT, patients diagnosed with breast cancer, will consecutively be recruited to participate. Participants will be randomized into one of three groups: MBSR Intervention I (weekly group sessions + self-instructing program), MBSR Intervention II (self-instructing program), and Controls (non-MBSR). Data will be collected before start of intervention, and 3, 6, and 12 months and thereafter yearly up to 5 years. This study may contribute to evidence-based knowledge concerning the efficacy of MBSR to support patient empowerment to regain health in breast cancer disease.Discussion: The present study may contribute to evidence-based knowledge concerning the efficacy of mindfulness training to support patient empowerment to regain health in a breast cancer disease. If MBSR is effective for symptom relief and quality of life, the method will have significant clinical relevance that may generate standard of care for patients with breast cancer.Trial registration: ClinicalTrials.gov: NCT01591915. © 2013 Kenne Sarenmalm et al.; licensee BioMed Central Ltd.

Ort, förlag, år, upplaga, sidor
BioMed Central, 2013
Nyckelord
Breast cancer, Mindfulness based stress reduction, Randomized controlled trials, Well-being, anxiety, article, controlled study, coping behavior, depression, empowerment, female, health, health care quality, health program, human, immune response, knowledge, longitudinal study, mood disorder, quality of life, randomized controlled trial, stress, study design, training, wellbeing
Nationell ämneskategori
Klinisk medicin
Forskningsämne
Medicin
Identifikatorer
urn:nbn:se:his:diva-8713 (URN)10.1186/1472-6882-13-248 (DOI)000325801100003 ()24088535 (PubMedID)2-s2.0-84884770463 (Scopus ID)
Tillgänglig från: 2014-01-02 Skapad: 2014-01-02 Senast uppdaterad: 2017-12-06Bibliografiskt granskad
Kenne Sarenmalm, E., Browall, M., Persson, L.-O., Fall-Dickson, J. M. & Gaston-Johansson, F. (2013). Relationship of sense of coherence to stressful events, coping strategies, health status, and quality of life in women with breast cancer. Psycho-Oncology, 22(1), 20-27
Öppna denna publikation i ny flik eller fönster >>Relationship of sense of coherence to stressful events, coping strategies, health status, and quality of life in women with breast cancer
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2013 (Engelska)Ingår i: Psycho-Oncology, ISSN 1057-9249, E-ISSN 1099-1611, Vol. 22, nr 1, s. 20-27Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Objective: To test the hypothesis that Antonovsky's concept of sense of coherence (SOC) predicts stressful events, coping strategies, health status, and quality of life (QoL) in a cohort of postmenopausal women (n = 131) with newly diagnosed primary or recurrent breast cancer.

Methods: Regression analyses of longitudinal data at baseline through 6 months following breast cancer diagnosis examined the relationships between SOC (13-item version), daily assessment of coping with stressful events, health status, and QoL (EORTC QLQ-30).

Results: The findings support Antonovsky's concept of SOC. Women with strong SOC reported fewer stressful events and more days without stressful events. They used more coping strategies and more frequently used distraction, situation redefinition, direct action, and relaxation, but seldom religion, to cope with stressful events, and reported better health status and QoL. Women with weak SOC experienced more distress and used fewer coping strategies, and they more frequently used coping strategies such as catharsis and seeking social and spiritual support, but seldom acceptance of the situation. They reported worse health status and QoL, regardless of disease stage or treatment. The relationships between SOC and health status and QoL were linear.

Conclusions: Sense of coherence significantly predicts distress, number and type of coping strategies such as direct action and relaxation, health status, and QoL in women with breast cancer. Our data suggest that the SOC scale may be a useful screening tool to identify individuals particularly vulnerable to distress and unable to cope adequately. Assessing SOC strength may assist health care providers to provide individualized patient interventions.

Ort, förlag, år, upplaga, sidor
John Wiley & Sons, 2013
Nyckelord
sense of coherence, stressful events, coping strategies, health status, quality of life, distress, breast cancer
Nationell ämneskategori
Medicin och hälsovetenskap
Forskningsämne
Medicin
Identifikatorer
urn:nbn:se:his:diva-5805 (URN)10.1002/pon.2053 (DOI)000313132100004 ()21910162 (PubMedID)2-s2.0-84872076301 (Scopus ID)
Tillgänglig från: 2012-04-30 Skapad: 2012-04-30 Senast uppdaterad: 2017-12-07Bibliografiskt granskad
Browall, M., Kenne Sarenmalm, E., Nasic, S., Wengström, Y. & Gaston-Johansson, F. (2013). Validity and Reliability of the Swedish Version of the Memorial Symptom Assessment Scale (MSAS): An Instrument for the Evaluation of Symptom Prevalence, Characteristics, and Distress. Journal of Pain and Symptom Management, 46(1), 131-141
Öppna denna publikation i ny flik eller fönster >>Validity and Reliability of the Swedish Version of the Memorial Symptom Assessment Scale (MSAS): An Instrument for the Evaluation of Symptom Prevalence, Characteristics, and Distress
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2013 (Engelska)Ingår i: Journal of Pain and Symptom Management, ISSN 0885-3924, E-ISSN 1873-6513, Vol. 46, nr 1, s. 131-141Artikel i tidskrift (Refereegranskat) Published
Ort, förlag, år, upplaga, sidor
Elsevier, 2013
Nyckelord
breast cancer, Memorial Symptom Assessment Scale, MSAS, Symptom, validation
Nationell ämneskategori
Omvårdnad
Forskningsämne
Medicin
Identifikatorer
urn:nbn:se:his:diva-7054 (URN)10.1016/j.jpainsymman.2012.07.023 (DOI)000321748500014 ()23195392 (PubMedID)2-s2.0-84880312150 (Scopus ID)
Tillgänglig från: 2013-01-25 Skapad: 2013-01-25 Senast uppdaterad: 2017-12-06Bibliografiskt granskad
Gaston-Johansson, F., Fall-Dickson, J. M., Nanda, J. P., Kenne Sarenmalm, E., Browall, M. & Goldstein, N. (2012). Long-term effect of the self-management comprehensive coping strategy program on quality of life in patients with breast cancer treated with high-dose chemotherapy. Psycho-Oncology, 22(3), 530-539
Öppna denna publikation i ny flik eller fönster >>Long-term effect of the self-management comprehensive coping strategy program on quality of life in patients with breast cancer treated with high-dose chemotherapy
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2012 (Engelska)Ingår i: Psycho-Oncology, ISSN 1057-9249, E-ISSN 1099-1611, Vol. 22, nr 3, s. 530-539Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

BACKGROUND: This study aims to examine the effectiveness of a self-management multimodal comprehensive coping strategy program (CCSP) on quality of life (QOL) among breast cancer patients 1 year after treatment.

METHODS: Patients (n = 110) with stage II, III, or IV breast cancer scheduled to receive high dose chemotherapy and autologous hematopoietic stem cell transplantation were randomized to either CCSP treatment or control group. The CCSP intervention was taught 2 week before hospital admission with reinforcement at specified times during treatment and 3 months after discharge. The CCSP components included educational information, cognitive restructuring, coping skills enhancement, and relaxation with guided imagery. Instruments administered at baseline included the following: Quality of Life Index-Cancer Version (QOLI-CV), State-Trait Anxiety Inventory, Beck Depression Inventory, and Coping Strategies Questionnaire. At 1-year follow-up, patients (n = 73) completed and returned the follow-up QOLI-CV.

RESULTS: Patients were mainly ≥40 years of age, married, Caucasian, and diagnosed with advanced breast cancer. A model measuring effectiveness of CCSP on QOL (total and subscale) at 1-year follow-up showed that the CCSP group (n = 38) had significant improvement in overall QOL (p < 0.01), health and functioning (p < 0.05), and socioeconomic (p < 0.05) and psychological/spiritual well-being (p < 0.01) compared with the control group (n = 35). The CCSP patients frequently used the CCSP to manage psychological (51%) and sleep problems (60%).

CONCLUSIONS: The CCSP improved QOL for patients at 1-year follow-up. Patients overwhelmingly reported that CCSP was beneficial. The CCSP as an effective coping intervention has potential as a self-management program for breast cancer survivors.

Ort, förlag, år, upplaga, sidor
John Wiley & Sons, 2012
Nyckelord
self-management, coping strategy, quality of life, high dose chemotherapy, breast cancer
Nationell ämneskategori
Medicin och hälsovetenskap
Forskningsämne
Medicin
Identifikatorer
urn:nbn:se:his:diva-5875 (URN)10.1002/pon.3031 (DOI)000315652500007 ()22290808 (PubMedID)2-s2.0-84874749049 (Scopus ID)
Tillgänglig från: 2012-05-14 Skapad: 2012-05-14 Senast uppdaterad: 2017-12-07Bibliografiskt granskad
Identifikatorer
ORCID-id: ORCID iD iconorcid.org/0000-0001-9559-0952

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