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  • Al-Yahri, Omer
    et al.
    Department of General Surgery, Hamad General Hospital, Doha, Qatar.
    Abdelaal, Abdelrahman
    Department of General Surgery, Hamad General Hospital, Doha, Qatar.
    El Ansari, Walid
    Högskolan i Skövde, Institutionen för hälsovetenskaper. Högskolan i Skövde, Forskningsmiljön hälsa, hållbarhet och digitalisering. Department of Surgery, Hamad General Hospital, Doha, Qatar / College of Medicine, Qatar University, Doha, Qatar.
    Farghaly, Hanan
    Department of Lab Medicine & Pathology, Hamad General Hospital, Doha, Qatar.
    Murshed, Khaled
    Department of Lab Medicine & Pathology, Hamad General Hospital, Doha, Qatar.
    Zirie, Mahmoud A.
    Department of Endocrinology, Hamad General Hospital, Doha, Qatar.
    Al Hassan, Mohamed S.
    Department of General Surgery, Hamad General Hospital, Doha, Qatar.
    First ever case report of co-occurrence of hobnail variant of papillary thyroid carcinoma and intrathyroid parathyroid adenoma in the same thyroid lobe2020Inngår i: International journal of surgery case reports, ISSN 2210-2612, E-ISSN 2210-2612, Vol. 70, s. 40-52Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Introduction: The hobnail variant of papillary thyroid cancer (PTC) is rare. Intrathyroid parathyroid adenoma (ITPA) is also rare. Co-ocurrence of PTC and ITPA in the same thyroid lobe is extremely rare. Likewise, primary hyperparathyroidism with such non-medullary thyroid carcinoma is rare. The specific molecular profile of hobnail PTC (HPTC) is different from the classic, poorly differentiated and anaplastic variants and may contribute to its aggressive behavior. HPTC's genetic profile remains unclear. Presentation of case: A 61-year-old woman presented to our endocrine clinic with generalized aches, bone pain, polyuria, and right neck swelling of a few months’ duration. Laboratory findings revealed hypercalcemia and hyperparathyroidism. Ultrasound of the neck showed 4.6 cm complex nodule within the right thyroid lobe. Sestamibi scan suggested parathyroid adenoma in the right thyroid lobe. Fine-needle aspiration (FNA) revealed atypical follicular lesion of undetermined significance. She underwent right lobectomy, which normalized the intraoperative intact parathyroid hormone levels. Final pathology with immunohistochemical stains demonstrated HPTC and IPTA (2 cm each). Next-generation sequencing investigated the mutation spectrum of HPTC and detected BRAFV600E mutation. Conclusions: A parathyroid adenoma should not exclude the diagnosis of thyroid carcinoma. Thyroid evaluation is needed for patients with primary hyperparathyroidism to prevent missing concurrent thyroid cancers. Cytomorphologic features to distinguish thyroid from parathyroid cells on FNA cytology must be considered. Immunohistochemical stains are important. BRAFV600E is the most common mutation in HPTC. This is possibly the first reported case of HPTC and ITPA co-occurring within the same thyroid lobe. Studies that define other molecular abnormalities may be useful as therapeutic targets. © 2020 The Author(s)

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  • Wennström, Berith
    et al.
    Högskolan i Skövde, Institutionen för hälsovetenskaper. Högskolan i Skövde, Forskningsmiljön hälsa, hållbarhet och digitalisering. Department of Anaesthesia, Skaraborg Hospital, Skövde, Sweden / Department of Surgery, Skaraborg Hospital, Skövde, Sweden / Research and Development Center, Skaraborg Hospital, Skövde, Sweden.
    Johansson, Anna
    Department of Surgery, Skaraborg Hospital, Skövde, Sweden.
    Kalabic, Sabina
    Department of Surgery, Skaraborg Hospital, Skövde, Sweden.
    E-son Loft, Anna-Lena
    Research and Development Center, Skaraborg Hospital, Skövde, Sweden..
    Skullman, Stefan
    Department of Surgery, Skaraborg Hospital, Skövde, Sweden.
    Bergh, Ingrid
    Högskolan i Skövde, Institutionen för hälsovetenskaper. Högskolan i Skövde, Forskningsmiljön hälsa, hållbarhet och digitalisering.
    Patient experience of health and care when undergoing colorectal surgery within the ERAS program2020Inngår i: Perioperative Medicine, ISSN 0908-6919, E-ISSN 2047-0525, Vol. 9, artikkel-id 15Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background

    Several studies show that the enhanced recovery after surgery (ERAS) program reduces complications postoperatively and leads to faster recovery and shorter hospital stays. However, little is known about patients’ self-reported health in an enhanced recovery context. The aim of this study was firstly to describe patient experiences of health within the concept of ERAS after colorectal (CR) surgery during a hospital stay and within 2 weeks of discharge. Secondly, to explore whether the ASA classification/co-morbidity, sex, and surgical method affect the patient’s experience of health.

    Methods

    Data were collected through the ERAS-HEALTH questionnaire, including two open-ended questions, and through telephone interviews postoperatively. Qualitative and quantitative analysis was used. Patients undergoing CR surgery (n = 80) were included from October 2016 to June 2018.

    Results

    The patients had mainly positive experiences of their hospital stay as well as most of them felt comfortable coming home. However, experienced state of health is affected by factors like surgical method and co-morbidity. Improvements were desired concerning information, food/food intake, pain management, and environment. At home, the patients experienced a lack of information about food/food intake and ostomy care. Decreased appetite and difficulties with micturition were also described. The most troublesome symptom was postoperative fatigue (POF). Analysis of the ERAS-HEALTH questionnaire showed that patients with higher co-morbidity and those who underwent open surgery have a significantly worse experience of their health compared with patients who underwent laparoscopy. However, it seems that the surgical method affects postoperative health to a greater extent than co-morbidity.

    Conclusions

    The patients reported many positive aspects and challenges when being cared for within the ERAS program. However, several improvements are needed to satisfy patient wishes regarding their care both in hospital and at home. Laparoscopic surgery affects patient state of health positively in several respects compared with open surgery.

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  • Altrabulsy, Osama
    Högskolan i Skövde, Institutionen för ingenjörsvetenskap.
    A Simulation-based Optimization Approach for Automated Vehicle Scheduling at Production Lines2019Independent thesis Advanced level (degree of Master (One Year)), 15 poäng / 22,5 hpOppgave
    Abstract [en]

    The world becomes more integrated and sophisticated, especially in the birth of advanced technologies, which have influenced all life aspects. Automated systems could be considered an example of those aspects, which have been affected by recent changes in today’s life. The competition in the market is putting increasing pressure on different manufacturing organizations to find the best methods that enable them to stay up to date with the latest technologies in the industrial field. One of the most famous dilemmas that exist in this field is designing an efficient and flexible material handling system. This issue draws the attention of both decision-makers in different companies and software developers who put considerable effort into making that desired system real. Inclusive research needs to be performed to obtain such a system, and the most significant part of the research that requires special attention is the applied methodology.The approach to be adapted determines the degree of stability of a particular material handling system to function effectively in the case studied. Several methods are available and could be implemented to design that effective system such as meta-heuristic algorithms, and approaches that depend on simulation software tools. The latter approach, which is the simulation approach, seems to get increasing attention from developers of the industrial system since it plays a vital role in reducing the cost and preserving available resources. Besides, it helps predict future changes and scenarios of the system to be analyzed.In this project, a discrete-event simulation model was built for the proposed layout of the main shop floor owned by a Swedish manufacturing company. The corporation located in the south of Sweden, and it produces a vast range of manufacture of goods. The chosen methodology is a combination of lean, simulation, and optimization approaches. It has been implemented on the proposed layout in which material is handled into production lines by using automated guided vehicles (AGVs) as a means of transportation. The analysis of results shows potential benefits, where the production process became more efficient and organized since the operational cost has been reduced by decreasing the number of required vehicles. Moreover, the simulation approach facilitated testing new ideas and designing improved scenarios without the necessity to change the current state of the factory layout or disturbing the regular activities.

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  • Isaeva, Elise
    et al.
    Högskolan i Skövde, Institutionen för hälsovetenskaper.
    Ahmady, Marina
    Högskolan i Skövde, Institutionen för hälsovetenskaper.
    Kvinnors upplevelser av att leva med bröstcancer: En litteraturöversikt2020Independent thesis Basic level (degree of Bachelor), 10 poäng / 15 hpOppgave
    Abstract [sv]

    Bakgrund:Bröstcancer är en vanlig sjukdom bland kvinnor och allt mer flera kvinnor drabbas. Det finns olika typer av bröstcancerbehandlingar. Alla behandlingar kan medföra biverkningar som kan påverka kvinnor både psykiskt och fysiskt. Sjuksköterskans roll och ansvar är att uppmärksamma dessa kvinnor i de olika stadierna av bröstcancer för att kunna ha koll på kvinnornas mående.Syfte: Syftet med denna studie var att beskriva kvinnors upplevelser av att leva med bröstcancer.Metod:Studien är en litteraturöversikts studie med kvalitativ och kvantitativ metod och består av 10 artiklar. Resultat: Består av ett huvudämne med två underteman och fyra subteman. Som visade att kvinnor upplevde att kroppslig förändring av bröstcancer och som resulterade i sociala konsekvenser. Konklusion: Studien visar att kvinnorna är i behov av ett stöd efter behandlingen av bröstcancer och att de upplever att den kroppsliga förändringen ger en stor påverkan i deras liv och vardag.

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  • Heikkilä, Katriina
    et al.
    Department of Health Services Research and Policy London School of Hygiene and Tropical Medicine London United Kingdom / Finnish Institute of Occupational Health Tampere, Helsinki and Turku Finland.
    Pentti, Jaana
    Department of Public Health University of Turku and Turku University Hospital Turku Finland / Department of Public Health University of Helsinki Finland.
    Madsen, Ida E. H.
    National Research Centre for the Working Environment Copenhagen Denmark.
    Lallukka, Tea
    Finnish Institute of Occupational Health Tampere, Helsinki and Turku Finland / Department of Public Health University of Helsinki Finland.
    Virtanen, Marianna
    Finnish Institute of Occupational Health Tampere, Helsinki and Turku Finland / Department of Public Health and Caring Sciences University of Uppsala Sweden / Stress Research Institute University of Stockholm Sweden.
    Alfredsson, Lars
    Centre for Occupational and Environmental Medicine Stockholm County Council Stockholm Sweden / Institute of Environmental Medicine Karolinska Institute Stockholm Sweden.
    Bjorner, Jakob
    National Research Centre for the Working Environment Copenhagen Denmark.
    Borritz, Marianne
    Department of Occupational and Environmental Medicine Bispebjerg Hospital Copenhagen University Copenhagen Denmark.
    Brunner, Eric
    Department of Epidemiology and Public Health University College London London United Kingdom.
    Burr, Hermann
    Federal Institute for Occupational Safety and Health Berlin Germany.
    Ferrie, Jane E.
    Department of Epidemiology and Public Health University College London London United Kingdom / Bristol Medical School: Population Health Sciences University of Bristol United Kingdom.
    Knutsson, Anders
    Department of Health Sciences Mid Sweden University Sundsvall Sweden.
    Koskinen, Aki
    Finnish Institute of Occupational Health Tampere, Helsinki and Turku Finland.
    Leineweber, Constanze
    Stress Research Institute University of Stockholm Sweden.
    Magnusson Hanson, Linda L.
    Stress Research Institute University of Stockholm Sweden.
    Nielsen, Martin L.
    Lægekonsulenten AS3 Companies Århus Denmark.
    Nyberg, Solja T.
    Department of Public Health University of Helsinki Finland.
    Oksanen, Tuula
    Finnish Institute of Occupational Health Tampere, Helsinki and Turku Finland.
    Pejtersen, Jan H.
    VIVE The Danish Center for Social Science Research Copenhagen Denmark.
    Pietiläinen, Olli
    Department of Public Health University of Helsinki Finland.
    Rahkonen, Ossi
    Department of Public Health University of Helsinki Finland.
    Rugulies, Reiner
    National Research Centre for the Working Environment Copenhagen Denmark / Department of Public Health and Department of Psychology University of Copenhagen Denmark.
    Singh-Manoux, Archana
    Department of Epidemiology and Public Health University College London London United Kingdom.
    Steptoe, Andrew
    Department of Epidemiology and Public Health University College London London United Kingdom.
    Suominen, Sakari
    Högskolan i Skövde, Institutionen för hälsovetenskaper. Högskolan i Skövde, Forskningsmiljön hälsa, hållbarhet och digitalisering. Department of Public Health University of Turku and Turku University Hospital Turku Finland.
    Theorell, Töres
    Stress Research Institute University of Stockholm Sweden.
    Vahtera, Jussi
    Department of Public Health University of Turku and Turku University Hospital Turku Finland.
    Väänänen, Ari
    Finnish Institute of Occupational Health Tampere, Helsinki and Turku Finland.
    Westerlund, Hugo
    Stress Research Institute University of Stockholm Sweden.
    Kivimäki, Mika
    Department of Public Health University of Helsinki Finland / Department of Epidemiology and Public Health University College London London United Kingdom.
    Job Strain as a Risk Factor for Peripheral Artery Disease: A Multi-Cohort Study2020Inngår i: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, ISSN 2047-9980, E-ISSN 2047-9980, Vol. 9, nr 9Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background Job strain is implicated in many atherosclerotic diseases, but its role in peripheral artery disease (PAD) is unclear. We investigated the association of job strain with hospital records of PAD, using individual-level data from 11 prospective cohort studies from Finland, Sweden, Denmark, and the United Kingdom. Methods and Results Job strain (high demands and low control at work) was self-reported at baseline (1985-2008). PAD records were ascertained from national hospitalization data. We used Cox regression to examine the associations of job strain with PAD in each study, and combined the study-specific estimates in random effects meta-analyses. We used τ2, I2, and subgroup analyses to examine heterogeneity. Of the 139 132 participants with no previous hospitalization with PAD, 32 489 (23.4%) reported job strain at baseline. During 1 718 132 person-years at risk (mean follow-up 12.8 years), 667 individuals had a hospital record of PAD (3.88 per 10 000 person-years). Job strain was associated with a 1.41-fold (95% CI, 1.11-1.80) increased average risk of hospitalization with PAD. The study-specific estimates were moderately heterogeneous (τ2=0.0427, I2: 26.9%). Despite variation in their magnitude, the estimates were consistent in both sexes, across the socioeconomic hierarchy and by baseline smoking status. Additional adjustment for baseline diabetes mellitus did not change the direction or magnitude of the observed associations. Conclusions Job strain was associated with small but consistent increase in the risk of hospitalization with PAD, with the relative risks on par with those for coronary heart disease and ischemic stroke.

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  • Cheng, Lan
    et al.
    Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany / Faculty of Mathematics and Computer Science, University of Bremen, Germany.
    Pohlabeln, Hermann
    Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany.
    Ahrens, Wolfgang
    Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany / Faculty of Mathematics and Computer Science, University of Bremen, Germany.
    Lauria, Fabio
    Institute of Food Sciences, National Research Council, Avellino, Italy.
    Veidebaum, Toomas
    Department of Chronic Diseases, National Institute for Health Development, Tallinn, Estonia.
    Chadjigeorgiou, Charalambos
    Research and Education Institute of Child Health, Strovolos, Cyprus.
    Molnár, Dénes
    Department of Pediatrics, Medical School, University of Pécs, Hungary.
    Eiben, Gabriele
    Högskolan i Skövde, Institutionen för hälsovetenskaper. Högskolan i Skövde, Forskningsmiljön hälsa, hållbarhet och digitalisering.
    Michels, Nathalie
    Department of Public Health, Faculty of Medicine and Health Sciences, Ghent University, Belgium.
    Moreno, Luis A.
    Genud (Growth, Exercise, Nutrition and Development) Research Group, Instituto Agroalimentario de Aragón (IA2), Instituto de Investigación Sanitaria Aragón (IIS Aragón), Centro de Investigacion Biomedica en Red Fisiopatologia de la Obesidad y Nutricion (CIBERObn), University of Zaragoza, Spain.
    Page, Angie S.
    Centre for Exercise, Nutrition and Health Sciences, University of Bristol, Bristol, United Kingdom.
    Pitsiladis, Yannis
    Collaborating Centre of Sports Medicine, University of Brighton, United Kingdom.
    Hebestreit, Antje
    Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen, Germany.
    Cross-sectional and longitudinal associations between physical activity, sedentary behaviour and bone stiffness index across weight status in European children and adolescents2020Inngår i: International Journal of Behavioral Nutrition and Physical Activity, ISSN 1479-5868, E-ISSN 1479-5868, Vol. 17, nr 1, artikkel-id 54Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Background: The associations between physical activity (PA), sedentary behaviour (SB) and bone health may be differentially affected by weight status during growth. This study aims to assess the cross-sectional and longitudinal associations between PA, SB and bone stiffness index (SI) in European children and adolescents, taking the weight status into consideration. Methods: Calcaneus SI was first measured by quantitative ultrasound among children aged 2-9 years old in 2007/08. It was measured again after 2 years in the IDEFICS study and after 6 years in the I. Family study. A sample of 2008 participants with time spent at sports clubs, watching TV and playing computer/games self-reported by questionnaire, and a subsample of 1037 participants with SB, light PA (LPA) and moderate-to-vigorous PA (MVPA) objectively measured using Actigraph accelerometers were included in the analyses. Weight status was defined as thin/normal and overweight/obese according to the extended International Obesity Task Force criteria. Linear mixed-effects models were used to estimate the cross-sectional and longitudinal associations between PA, SB and SI percentiles, stratified by weight status. Results: The cross-sectional association between weekly duration of watching TV and SI percentiles was negative in thin/normal weight group (β =-0.35, p = 0.008). However, baseline weekly duration of watching TV (β =-0.63, p = 0.021) and change after 2 years (β =-0.63, p = 0.022) as well as the change in weekly duration of playing computer/games after 6 years (β =-0.75, p = 0.019) were inversely associated with corresponding changes in SI percentiles in overweight/obese group. Change in time spent at sports clubs was positively associated with change in SI percentiles after 2 years (β = 1.28, p = 0.001), with comparable effect sizes across weight status. In the subsample with accelerometer data, we found a positive cross-sectional association between MVPA and SI percentiles in thin/normal weight group. Baseline MVPA predicted changes in SI percentiles after 2 and 6 years in all groups. Conclusions: Our results suggested the beneficial effect of PA on SI. However, the increasing durations of screen-based SB might be risk factors for SI development, especially in overweight/obese children and adolescents. © 2020 The Author(s).

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  • El Ansari, Walid
    et al.
    Högskolan i Skövde, Institutionen för hälsovetenskaper. Högskolan i Skövde, Forskningsmiljön hälsa, hållbarhet och digitalisering. Department of Surgery, Hamad General Hospital, Hamad Medical Corporation, Doha 3050, Qatar / College of Medicine, Qatar University, Doha 2713, Qatar .
    El-Menyar, Ayman
    Department of Surgery, Trauma and Vascular Surgery, Clinical Research, Hamad General Hospital, Doha 3050, Qatar / Clinical Medicine, Weill Cornell Medical School, Doha 24144, Qatar.
    Is routine preoperative esophagogastroduodenscopy prior to bariatric surgery mandatory?: Protocol for a systematic review and meta-analysis2020Inngår i: International Journal of Surgery Protocols, ISSN 2468-3574, Vol. 22, s. 1-5Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Introduction: Routine preoperative esophagogastroduodenscopy (p-EGD) prior to bariatric surgery (BS) is currently widely undertaken, and hence an important issue with many clinical and financial repercussions. Yet, the true extent of why p-EGD is routinely undertaken for all bariatric patients remains not well understood. Methods and analysis: To address this, we will undertake a systematic review and meta-analysis of routine p-EGD prior to BS from around the world. This protocol describes the methodological approach to be adopted and outlines the search strategies and eligibility criteria that will be employed to identify and select studies, and the way by which data from the selected studies will be extracted for analysis. PubMed, Cochrane Central Register of Controlled Trials (CENTRAL), WHO International Clinical Trials Registry Platform, Cochrane Library, MEDLINE, Scopus, clinicaltrials.gov and Google scholar will be searched from 01 January 2000 to 30 April 2019 for original studies written in English that provided prevalence estimates of the outcomes of routine p-EGD prior to BS. STROBE criteria will assess the methodological quality of the selected studies. The use of fixed or random effects model will depend on the results of statistical tests for heterogeneity. Publication bias will be visually estimated by assessing funnel plots. Pooled estimates will be calculated. This protocol conforms to the Preferred Reporting Items for Systematic reviews and Meta-Analysis (PRISMA) guidelines and has been submitted for registration at the PROSPERO International Prospective Register of systematic reviews. No ethical clearance is required for this study. This review will be published in a peer- reviewed journal and will be presented at various national and international conferences. © 2020 The Author(s)

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  • Nordén, Johan
    Högskolan i Skövde, Institutionen för biovetenskap.
    Assessment of methods for microRNA isolation, microRNA amplification, and development of a normalization strategy for sepsis biomarker research2020Independent thesis Advanced level (degree of Master (Two Years)), 20 poäng / 30 hpOppgave
    Abstract [en]

    Sepsis, defined by organ dysfunction caused by an adverse immune response of the host to an infection, comes with considerable cost in human lives and as a substantial burden financially. Significant upgrades have been made over the past two decades when diagnosing and treating sepsis but still with room for improvements. Early detection is a cornerstone in the fight against sepsis, and the focus on strengthening diagnostics is in the forefront of modern research. The implementation of biomarkers may be the path of progression in this objective. This study aimed at establishing procedural foundations when using microRNAs as potential biomarkers. The study conducted looked at: (1) Isolation procedure, of microRNA from human plasma, of three kits: Total RNA Purification Kit (Norgen Biotech), miRNAeasy Serum/Plasma Kit (Qiagen), and miRNeasy Serum/Plasma Advanced Kit (Qiagen). (2) Amplification of miRNA through two Reverse Transcription Quantitative PCR methods: Two-tailed RT-qPCR (TATAA Biocenter), and miRCURY LNA miRNA PCR (Qiagen). (3) Developing a normalization strategy by identifying miRNA reference targets in a geNorm pilot experiment. Qubit analysis revealed that the two isolation kits from Qiagen performed similar, and better that the Norgen kit. The Two-tailed RT-qPCR failed to amplify miRNA samples, whereas the miRCURY LNA miRNA PCR showed consistent amplification across samples with a high call rate. The geNorm analysis concluded that hsa-miR-425-5p and hsa-miR-93-5p was the optimal reference target set. The study demonstrated that the isolation kits from Qiagen coupled with the miRCURY LNA miRNA PCR is a viable option for future miRNA biomarker studies.

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  • Strandberg, Johanna
    et al.
    Högskolan i Skövde, Institutionen för hälsovetenskaper.
    Melin, Lovisa
    Högskolan i Skövde, Institutionen för hälsovetenskaper.
    Kvinnors upplevelser att vara drabbad av bröstcancer: En studie av självbiografier2020Independent thesis Basic level (degree of Bachelor), 10 poäng / 15 hpOppgave
    Abstract [sv]

    Bakgrund: I Sverige är den vanligaste cancerformen kvinnor drabbas av bröstcancer. Då kvinnor fortfarande är i arbetsför ålder kan sjukdomen även drabba familjelivet och arbetet. När diagnosen ställs förändras livsvärlden för kvinnan då behandlingar samt andra förändringar kommer att bli en ny del av vardagen. Syfte: Syftet är att belysa kvinnors upplevelser av att vara drabbad av bröstcancer. Metod: Studien grundades på sex självbiografier som har analyserats enligt en kvalitativ innehållsanalys vilket skapade olika kategorier. Resultat: Fem kategorier och tio underkategorier bildades som belyste livsvärldsförändringar för kvinnor, känslor kring den förändrade kroppen och anhörigas inverkar. För kvinnor är det många känslor av rädsla, ångest och oro som påverkar och det tar även tid för kvinnor att acceptera vad som hänt. Diskussion: Den förändrade livsvärlden som uppkom för drabbade kvinnor innehåller aspekter om både det psykiska måendet samt om hur den fysiska kroppen förändras. Konklusion: Bröstcancerdrabbade kvinnor upplevde en förändrad livsvärld då det uppstod kroppsliga förändringar samt svårigheter med att få ihop en fungerade vardag. Kvinnor upplevde att stödet från anhöriga och sjuksköterskan är betydelsefullt för att främja en god livsvärld. Genom att förstå hur förändringarna påverkar bröstcancerdrabbade kvinnor kan sjuksköterskan möta kvinnors livsvärld på bästa sätt.

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  • Nanni, Mirco
    et al.
    CNR, ISTI, Rome, Italy.
    Andrienko, Gennady
    IAIS Fraunhofer, Germany / City University London, England, UK.
    Barabási, Albert-László
    Northeastern University, Boston, USA.
    Boldrini, Chiara
    CNR, IIT, Rome, Italy.
    Bonchi, Francesco
    ISI Foundation, Italy / Eurecat, Spain.
    Cattuto, Ciro
    University of Torino, Italy / ISI Foundation, Italy.
    Chiaromonte, Francesca
    Sant’Anna School of Advanced Studies Pisa, Italy / Penn State University, USA.
    Comande, Giovanni
    Sant’Anna School of Advanced Studies Pisa, Italy.
    Conti, Marco
    IIT-CNR, Italy.
    Coté, Mark
    King’s College London, UK.
    Dignum, Frank
    Umeå University, Sweden.
    Dignum, Virginia
    Umeå University, Sweden.
    Domingo-Ferrer, Josep
    Universitat Rovira i Virgili, Catalonia.
    Ferragina, Paolo
    University of Pisa, Italy.
    Giannotti, Fosca
    ISTI-CNR, Italy.
    Guidotti, Riccardo
    University of Pisa, Italy.
    Helbing, Dirk
    ETH Zurich, Switzerland.
    Kaski, Kimmo
    Aalto University School of Science, Finland.
    Kertesz, Janos
    Central European University, Hungary.
    Lehmann, Sune
    Technical University of Denmark.
    Lepri, Bruno
    FBK, Italy.
    Lukowicz, Paul
    DFKI, Germany.
    Matwin, Stan
    Dalhousie University, Canada / Polish Academy of Sciences, Poland.
    Jiménez, David Megías
    Universitat Oberta de Catalunya.
    Monreale, Anna
    University of Pisa, Italy.
    Morik, Katharina
    TU Dortmund University, Germany.
    Oliver, Nuria
    ELLIS Alicante, Spain / Data-Pop Alliance, USA.
    Passarella, Andrea
    IIT-CNR, Italy.
    Passerini, Andrea
    Universita degli Studi di Trento.
    Pedreschi, Dino
    University of Pisa, Italy.
    Pentland, Alex
    MIT, USA.
    Pianesi, Fabio
    EIT Digital, Italy.
    Pratesi, Francesca
    University of Pisa, Italy.
    Rinzivillo, Salvatore
    ISTI-CNR, Italy.
    Ruggieri, Salvatore
    University of Pisa, Italy.
    Siebes, Arno
    Universiteit Utrecht, The Netherlands.
    Torra, Vicenç
    Högskolan i Skövde, Institutionen för informationsteknologi. Högskolan i Skövde, Forskningsmiljön Informationsteknologi. Maynooth University, Ireland.
    Trasarti, Roberto
    ISTI-CNR, Italy.
    van den Hoven, Jeroen
    TU Delft, The Netherlands.
    Vespignani, Alessandro
    Northeastern University, USA.
    Give more data, awareness and control to individual citizens, and they will help COVID-19 containment2020Inngår i: Transactions on Data Privacy, ISSN 1888-5063, E-ISSN 2013-1631, Vol. 13, nr 1, s. 61-66Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    The rapid dynamics of COVID-19 calls for quick and effective tracking of virus transmission chains and early detection of outbreaks, especially in the "phase 2" of the pandemic, when lockdown and other restriction measures are progressively withdrawn, in order to avoid or minimize contagion resurgence. For this purpose, contact-tracing apps are being proposed for large scale adoption by many countries. A centralized approach, where data sensed by the app are all sent to a nation-wide server, raises concerns about citizens' privacy and needlessly strong digital surveillance, thus alerting us to the need to minimize personal data collection and avoiding location tracking. We advocate the conceptual advantage of a decentralized approach, where both contact and location data are collected exclusively in individual citizens' "personal data stores", to be shared separately and selectively (e.g., with a backend system, but possibly also with other citizens), voluntarily, only when the citizen has tested positive for COVID-19, and with a privacy preserving level of granularity. This approach better protects the personal sphere of citizens and affords multiple benefits: it allows for detailed information gathering for infected people in a privacy-preserving fashion; and, in turn this enables both contact tracing, and, the early detection of outbreak hotspots on more finely-granulated geographic scale. The decentralized approach is also scalable to large populations, in that only the data of positive patients need be handled at a central level. Our recommendation is two-fold. First to extend existing decentralized architectures with a light touch, in order to manage the collection of location data locally on the device, and allowthe user to share spatio-temporal aggregates - if and when they want and for specific aims - with health authorities, for instance. Second, we favour a longerterm pursuit of realizing a Personal Data Store vision, giving users the opportunity to contribute to collective good in the measure they want, enhancing self-awareness, and cultivating collective efforts for rebuilding society.

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  • Noreika, Valdas
    et al.
    Department of Psychology, University of Cambridge, United Kingdom / Department of Psychology and Speech-Language Pathology, University of Turku, Finland.
    Windt, Jennifer M.
    Department of Philosophy, Monash University, Clayton, VIC, Australia.
    Kern, Markus
    Translational Neurotechnology Lab, University of Freiburg, Germany.
    Valli, Katja
    Högskolan i Skövde, Institutionen för biovetenskap. Högskolan i Skövde, Forskningsmiljön Systembiologi. Department of Psychology and Speech-Language Pathology, University of Turku, Finland.
    Salonen, Tiina
    Department of Psychology and Speech-Language Pathology, University of Turku, Finlan.
    Parkkola, Riitta
    Department of Radiology, University and University Hospital of Turku, Finland.
    Revonsuo, Antti
    Högskolan i Skövde, Institutionen för biovetenskap. Högskolan i Skövde, Forskningsmiljön Systembiologi.
    Karim, Ahmed A.
    Department of Psychiatry and Psychotherapy, University of Tübingen, Germany / Department of Psychology and Neuroscience, Jacobs University, Bremen, Germany / Department of Health Psychology and Neurorehabilitation, SRH Mobile University, Riedlingen, Germany.
    Ball, Tonio
    Translational Neurotechnology Lab, University of Freiburg, Germany.
    Lenggenhager, Bigna
    Department of Psychology, University of Zurich, Switzerland.
    Modulating dream experience: Noninvasive brain stimulation over the sensorimotor cortex reduces dream movement2020Inngår i: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 10, nr 1, artikkel-id 6735Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Recently, cortical correlates of specific dream contents have been reported, such as the activation of the sensorimotor cortex during dreamed hand clenching. Yet, despite a close resemblance of such activation patterns to those seen during the corresponding wakeful behaviour, the causal mechanisms underlying specific dream contents remain largely elusive. Here, we aimed to investigate the causal role of the sensorimotor cortex in generating movement and bodily sensations during REM sleep dreaming. Following bihemispheric transcranial direct current stimulation (tDCS) or sham stimulation, guided by functional mapping of the primary motor cortex, naive participants were awakened from REM sleep and responded to a questionnaire on bodily sensations in dreams. Electromyographic (EMG) and electroencephalographic (EEG) recordings were used to quantify physiological changes during the preceding REM period. We found that tDCS, compared to sham stimulation, significantly decreased reports of dream movement, especially of repetitive actions. Other types of bodily experiences, such as tactile or vestibular sensations, were not affected by tDCS, confirming the specificity of stimulation effects to movement sensations. In addition, tDCS reduced EEG interhemispheric coherence in parietal areas and affected the phasic EMG correlation between both arms. These findings show that a complex temporal reorganization of the motor network co-occurred with the reduction of dream movement, revealing a link between central and peripheral motor processes and movement sensations of the dream self. tDCS over the sensorimotor cortex interferes with dream movement during REM sleep, which is consistent with a causal contribution to dream experience and has broader implications for understanding the neural basis of self-experience in dreams. © 2020, The Author(s).

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  • Bjerkeli, Pernilla J.
    et al.
    Högskolan i Skövde, Institutionen för hälsovetenskaper. Högskolan i Skövde, Forskningsmiljön hälsa, hållbarhet och digitalisering.
    Skoglund, Ingmarie
    Department of Primary Health Care, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden / Research and Development Department, Region Västra Götaland, Borås, Sweden.
    Holmgren, Kristina
    Department of Health and Rehabilitation, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
    Does early identification of high work related stress affect pharmacological treatment of primary care patients?: Analysis of Swedish pharmacy dispensing data in a randomised control study2020Inngår i: BMC Family Practice, ISSN 1471-2296, E-ISSN 1471-2296, Vol. 21, nr 1, artikkel-id 70Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    BACKGROUND: The study is part of a randomised controlled trial with the overall aim to evaluate if use of the Work Stress Questionnaire (WSQ), combined with feedback at consultation, can be used by healthcare professionals in primary health care to prevent sickness absence. The specific aim of the present study was to investigate whether there were differences in pharmacy dispensing of prescription medications between the intervention group and the control group. METHODS: The study was a randomized controlled trial. Non-sick-listed employed women and men, aged 18 to 64 years, seeking care at primary health care centres (PHCCs) were eligible participants. The intervention included early identification of work-related stress by the WSQ, general practitioner (GP) training and GP feedback at consultation. Pharmacy dispensing data from the Swedish Prescription Drug Register for a period of 12 months following the intervention was used. Primary outcomes were the number of different medications used, type of medication and number of prescribing clinics. Data was analysed using Mann Whitney U tests and chi-square tests. RESULTS: The study population included 271 individuals (132 in the intervention group and 139 in the control group). The number of different medications used per individual did not differ significantly between the control group (median 4.0) and the intervention group (median 4.0, p-value 0.076). The proportion of individuals who collected more than 10 different medications was higher in the control group than in the intervention group (15.8% versus 4.5%, p = 0.002). In addition, the proportion of individuals filling prescriptions issued from more than three different clinics was higher in the control group than in the intervention group (17.3% versus 6.8%, p = 0.007). CONCLUSION: Systematic use of the WSQ combined with training of GPs and feedback at consultation may affect certain aspects of pharmacological treatment in primary health care patients. In this randomised control trial, analysis of pharmacy dispensing data show that patients in the intervention group had less polypharmacy and filled prescriptions issued from a smaller number of different clinics. TRIAL REGISTRATION: ClinicalTrials.gov. Identifier: NCT02480855. Registered 20 May 2015.

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  • Keane, Simon
    et al.
    Högskolan i Skövde, Institutionen för hälsovetenskaper. Högskolan i Skövde, Forskningsmiljön hälsa, hållbarhet och digitalisering.
    Améen, Sophie
    Högskolan i Skövde, Institutionen för hälsovetenskaper. Högskolan i Skövde, Forskningsmiljön hälsa, hållbarhet och digitalisering.
    Lindlöf, Angelica
    Högskolan i Skövde, Institutionen för biovetenskap. Högskolan i Skövde, Forskningsmiljön Systembiologi.
    Ejeskär, Katarina
    Högskolan i Skövde, Institutionen för hälsovetenskaper. Högskolan i Skövde, Forskningsmiljön hälsa, hållbarhet och digitalisering.
    Low DLG2 gene expression, a link between 11q-deleted and MYCN-amplified neuroblastoma, causes forced cell cycle progression, and predicts poor patient survival2020Inngår i: Cell Communication and Signaling, ISSN 1478-811X, E-ISSN 1478-811X, Vol. 18, nr 1, artikkel-id 65Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    BACKGROUND: Neuroblastoma (NB) is a childhood neural crest tumor. There are two groups of aggressive NBs, one with MYCN amplification, and another with 11q chromosomal deletion; these chromosomal aberrations are generally mutually exclusive. The DLG2 gene resides in the 11q-deleted region, thus makes it an interesting NB candidate tumor suppressor gene. METHODS: We evaluated the association of DLG2 gene expression in NB with patient outcomes, stage and MYCN status, using online microarray data combining independent NB patient data sets. Functional studies were also conducted using NB cell models and the fruit fly. RESULTS: Using the array data we concluded that higher DLG2 expression was positively correlated to patient survival. We could also see that expression of DLG2 was inversely correlated with MYCN status and tumor stage. Cell proliferation was lowered in both 11q-normal and 11q-deleted NB cells after DLG2 over expression, and increased in 11q-normal NB cells after DLG2 silencing. Higher level of DLG2 increased the percentage of cells in the G2/M phase and decreased the percentage of cells in the G1 phase. We detected increased protein levels of Cyclin A and Cyclin B in fruit fly models either over expressing dMyc or with RNAi-silenced dmDLG, indicating that both events resulted in enhanced cell cycling. Induced MYCN expression in NB cells lowered DLG2 gene expression, which was confirmed in the fly; when dMyc was over expressed, the dmDLG protein level was lowered, indicating a link between Myc over expression and low dmDLG level. CONCLUSION: We conclude that low DLG2 expression level forces cell cycle progression, and that it predicts poor NB patient survival. The low DLG2 expression level could be caused by either MYCN-amplification or 11q-deletion. Video Abstract.

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  • Gillsjö, Catharina
    et al.
    Högskolan i Skövde, Institutionen för hälsovetenskaper. Högskolan i Skövde, Forskningsmiljön hälsa, hållbarhet och digitalisering. College of Nursing, University of Rhode Island, Kingston, United States.
    Nässén, Kristina
    Academy of Care, Working Life and Social Welfare, University of Borås, Sweden.
    Berglund, Mia
    Högskolan i Skövde, Forskningsmiljön hälsa, hållbarhet och digitalisering. Högskolan i Skövde, Institutionen för hälsovetenskaper.
    Suffering in silence: a qualitative study of older adults’ experiences of living with long-term musculoskeletal pain at home2020Inngår i: European Journal of Ageing, ISSN 1613-9372, E-ISSN 1613-9380Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Long-term musculoskeletal pain is a major, disabling, and often undertreated health problem among the increasing number of older adults worldwide. However, there is limited knowledge of community-dwelling older adults’ experiences of living with this type of pain. The aim of the study was to deepen the understanding of the phenomenon: how older adults experience living with long-term musculoskeletal pain at home. The study design was an inductive qualitative Reflective Lifeworld Research approach grounded in phenomenological epistemology. Data were obtained from 20 community-dwelling older adults, aged 72–97 years. Data were collected through open-ended interviews and analyzed to understand the meanings of the phenomenon. The essence of the phenomenon entailed suffering in silence and encompassed the following constituents: loneliness and restrictions in daily living; ways to endure and distract from pain; not being taken seriously; fear of the future; and valuing joy and meaning in life. Living with long-term musculoskeletal pain restricts access to the world and leads to a suffering in silence. Finding ways to endure and distract from pain and to focus on issues that give joy and meaning in life is predominant in efforts to balance restraints from pain in life. Suffering is reinforced by loneliness, a sense of not being taken seriously by health care providers and fear of an uncertain future. It is necessary to foster increased attentiveness and sensitivity in meeting the needs of each older adult and provide a care that alleviates suffering and preserves and promotes health and well-being. © 2020, The Author(s).

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  • Ademi, Gzim
    Högskolan i Skövde, Institutionen för hälsovetenskaper.
    Det nya livet för patienten: En kvalitativ litteraturöversikt om patientens upplevelser av diabetes typ 22020Independent thesis Basic level (degree of Bachelor), 10 poäng / 15 hpOppgave
    Abstract [sv]

    Bakgrund: Sjukdomen diabetes typ 2 är en kronisk sjukdom som ständigt ökar runt om i världen. Sjukdomen medför ett lidande för patienten, vilket leder till att livskvaliteten försämras. Därför är egenvård viktigt för att patienterna inte ska besväras av komplikationerna. Syftet: Beskriva patientens upplevelser att leva med diabetes typ 2. Metod: En litteraturöversikt baserad på 12 kvalitativa artiklar. Resultat: Består av tre teman; påfrestningar att leva med diabetes, ansvar för sin livsstilsförändring och stöd från omgivningen. Dessa tre teman bilda sex subteman; livskvaliteten försämras, det skapar oro, en ständig kamp att förändra kosten, viljan att kunna röra sig, stöd från närstående och stöd från vården. Resultatet visar på en ständig kamp för patienten att hantera diabetes typ 2, då det skapar oro och rädsla över komplikationerna som diabetes kan leda till. Det visar också hur påfrestande det är med nya livsstilsförändringar när det gäller kost och fysisk aktivitet. Närstående och vården har en betydande roll när det gäller stöd till patienterna. Slutsats: Visar hur viktigt det är att patienter får stöd både från vården och närstående för att öka motivationen till att ändra sina livsstilsförändringar och minska riskerna för komplikationer.

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  • Hansson, Linn
    et al.
    Högskolan i Skövde, Institutionen för hälsovetenskaper.
    Heshmati, Parastu
    Högskolan i Skövde, Institutionen för hälsovetenskaper.
    Individers upplevelser av att leva med kronisk sjukdom2020Independent thesis Basic level (degree of Bachelor), 10 poäng / 15 hpOppgave
    Abstract [sv]

    Bakgrund: Kronisk sjukdom är den ledande dödsorsaken bland individer världen över varav hjärt-kärlsjukdom, cancer, diabetes och kroniska lungsjukdomar är de dominerande. Att leva med kronisk sjukdom erfordrar en livslång behandling av förändrade levnadsvanor. Hälsa och välbefinnande utesluter inte sjukdom, för kroniskt drabbade innebär det att förhålla sig till sin livssituation. Subjektiva och objektiva emotioner är en stor del bland individers vardag och orsakar ett lidande. Hos hälso- och sjukvården föreligger det ett ansvar att främja hälsa, lindra lidande och förebygga sjukdom bland individer med kronisk sjukdom. Syfte: Att belysa individers upplevelser av att leva med kronisk sjukdom. Metod: En litteraturöversikt där datamaterialet består av tio kvalitativa artiklar ur ett patientperspektiv. Resultat: Resultatet identifierar två huvudteman; behov av ett stödjande nätverk och kronisk sjukdom i vardagen samt sju underteman; vikten av ett betryggande och socialt stöd, en förtroendefull vårdrelation, kunskap och information vid sjukdomshantering, att finna balans vid upprätthållandet av levnadsvanor, när sjukdomen är under progression, avsaknad av en meningsfull vardag och existentiell rädsla. Konklusion: Individer med kronisk sjukdom upplever ett dagligt och påtagligt livslidande. Individer bör ses ur ett helhetsperspektiv där hälso- och sjukvården skall utgå från en personcentrerad- och individanpassad vård.

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  • Leidenberger, Sonja
    et al.
    Högskolan i Skövde, Institutionen för biovetenskap. Högskolan i Skövde, Forskningsmiljön Systembiologi.
    Boström, Sven
    Swedish Museum of Natural History, Department of Zoology, Stockholm, Sweden.
    Wayland, Matthew Thomas
    University of Cambridge, United Kingdom.
    Host records and geographical distribution of Corynosoma magdaleni, C. semerme and C. strumosum (Acanthocephala: Polymorphidae)2020Inngår i: Biodiversity Data Journal, ISSN 1314-2836, E-ISSN 1314-2828, Vol. 8, artikkel-id e50500Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    A literature survey was conducted to investigate the host and geographical distribution patterns of three Corynosoma species (Acanthocephala: Polymorphidae), viz. C. magdaleni, C. semerme and C. strumosum. All three species appear to be restricted to the Northern Hemisphere. Occurrence records of C. magdaleni are limited to the Northern Atlantic coasts, while C. semerme has a circumpolar distribution. The geographical range of Corynosoma strumosum encompasses the distributions of the other two species, but also extends into warmer southern regions. Some Corynosoma populations are living with their definitive hosts in very isolated locations, such as in the brackish Baltic Sea or different freshwater lakes (e.g. Lake Saimaa). All three species have a heteroxenous life cycle, comprising a peracaridan intermediate host, a fish paratenic host and a mammalian definitive host. Occasionally, an acanthocephalan may enter an accidental host, from which it is unable to complete its life cycle. The host records reported here are categorised by type, i.e. intermediate, paratenic, definitive or accidental. While most of the definitive hosts are shared amongst the three Corynosoma species, C. strumosum showed the broadest range of paratenic hosts, which reflects its more extensive geographical distribution. One aim of this study and extensive literature summary is to guide future sampling efforts therewith contribute to throw more light on the on-going species and morphotype discussion for this interesting parasite species.

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  • Sahat, Haris
    Högskolan i Skövde, Institutionen för hälsovetenskaper.
    Stroke – en förändrad vardag: En litteraturbaserad studie2020Independent thesis Basic level (degree of Bachelor), 10 poäng / 15 hpOppgave
    Abstract [sv]

    Bakgrund: Stroke är en vanlig sjukdom och ökar bland personer som är yngre än 65 år. Sjukdomen orsakar en del förändringar vilket gör att patienterna måste anpassa sig till sitt nya liv. Denna anpassning kan de inte göra själva utan är i behov av hjälp av vården. Personalen behöver en uppfattning om hur de kan hjälpa till stroke patienter och behöver därför en insyn i deras liv post-stroke. Syfte: Syftet med denna studie var att beskriva hur personer i arbetsför ålder upplever att deras dagliga liv förändras efter en stroke. Metod: En litteraturbaserad metod användes med grund i kvalitativ forskning. Resultat: Ur analysen av datamaterialet framträdde tre kategorier; förändrad roll; känslomässiga konsekvenser och förändring av dagliga aktiviteter och sex underkategorier. Konklusion: När personer i arbetsför ålder drabbas av stroke blir det en helomvändning av livet. Fysiska nedsättningar och hinder som uppstår leder till ett livslidande. Självständigheten förloras samtidigt som behov och stöd av andra ökar. En situation uppstår där hjälp behövs från vården.

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  • Nilsson, Jesper
    et al.
    Högskolan i Skövde, Institutionen för ingenjörsvetenskap.
    Shamoun, Steven
    Högskolan i Skövde, Institutionen för ingenjörsvetenskap.
    Decision Support for new Process Design via Discrete-event Simulation2019Independent thesis Basic level (degree of Bachelor), 20 poäng / 30 hpOppgave
    Abstract [en]

    As a result of the technical breakthrough of modern age, manufacturing organisations are put through immense pressure to continually improve their internal processes with the purpose of economic growth in order to stay competitive in the global market. Thus, making trial and error obsolete in the real world systems, in relation to calculated decision making. This thesis aims to facilitate the decision making basis for the partner companies’ future production design by measuring its expected productivity with the purpose to further strengthen the collaboration with the customer, by the use of discrete-event simulation.AB Furhoffs Rostfria is a family-owned company with its base in Skövde that manufactures and pro-cesses stainless steel products and specialises in three central departments, plumbing, kitchen, and subcontracting products. This thesis focus is within the production of heat shields in the department of subcontracting products as they are projecting an annual increase of 20%.The project was initialised with a pre-study phase that includes the theoretical framework, covering all main subjects to be presented along with analysing relevant literature studies for valuable insight into previous studies within the same field. Following a method and execution phase was carried out coher-ently with creating a simulation model and data collection. Different scenarios in the simulation model have been presented to the partner company along with wastes that have been observed within the production flow during Gemba.The different scenarios in the simulation model included, for instance, the production of both bigger and smaller batch sizes for each variant to analyse how that factor correlates with the product lead time and to also find out what the most optimal batch sizes would be for the respective variant in order to build full pallets. The future state production was evaluated and the results reduced the mean lead time by roughly 59% compared to the current state production.

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  • Majzoub, Ahmad
    et al.
    Department of Urology, Hamad Medical Corporation, Doha, Qatar / Department of Urology, Weill Cornell Medicine-Qatar, Doha, Qatar.
    Arafa, Mohamed
    Department of Urology, Hamad Medical Corporation, Doha, Qatar / Department of Urology, Weill Cornell Medicine-Qatar, Doha, Qatar / Department of Andrology, Cairo University, Egypt.
    El Ansari, Walid
    Högskolan i Skövde, Institutionen för hälsovetenskaper. Högskolan i Skövde, Forskningsmiljön hälsa, hållbarhet och digitalisering. Department of Surgery, Hamad Medical Corporation, Doha, Qatar / College of Medicine, Qatar University, Doha, Qatar.
    Mahdi, Mohammed
    Department of Urology, Hamad Medical Corporation, Doha, Qatar.
    Agarwal, Ashok
    Department of Urology, Glickman Urology and Kidney Institute, Cleveland Clinic Foundation, OH, United States.
    Al-Said, Sami
    Department of Urology, Hamad Medical Corporation, Doha, Qatar / Department of Urology, Weill Cornell Medicine-Qatar, Doha, Qatar.
    Elbardisi, Haitham
    Department of Urology, Hamad Medical Corporation, Doha, Qatar / Department of Urology, Weill Cornell Medicine-Qatar, Doha, Qatar.
    Correlation of oxidation reduction potential and total motile sperm count: its utility in the evaluation of male fertility potential2020Inngår i: Asian Journal of Andrology, ISSN 1008-682X, E-ISSN 1745-7262, Vol. 22, nr 3, s. 317-322Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Oxidative stress (OS) is detrimental to sperm functions, and the oxidation reduction potential (ORP) is a good measure of OS as it considers the balance between oxidants and reductants. Total motile sperm count (TMSC) is viewed as the single most important semen analysis parameter that can predict male infertility severity, and its correlation with ORP has never been undertaken. The objectives of this study were to assess the correlation between ORP and TMSC, to identify the ORP cutoff value based on the TMSC result, and to compare this cutoff value with previously reported ORP cutoff values in literature. One thousand one hundred and sixty-eight infertile patients and 100 fertile controls were enrolled. Demographic and semen data of the participants were retrieved and analyzed. Wilcoxon's rank-sum test compared variables between infertile men and fertile controls; Spearman's correlation assessed the static ORP (sORP)-TMSC relationship for the whole sample and among each group individually. Using a 20×106TMSC threshold, receiver operator characteristic (ROC) analysis determined the sORP cutoff associated with the highest predictive values. TMSC was significantly negatively correlated with sORP across all participants (r = 0.86, P < 0.001), among infertile patients (r = 0.729, P < 0.001), and among fertile controls (r = 0.53, P < 0.001). A 20-million TMSC threshold determined an sORP cutoff value of 2.34 mV/106sperm/ml to be associated with 82.9% sensitivity, 82.8% specificity, 91.5% positive predictive value (PPV), 68.5% negative predictive value (NPV), and 82.9% overall accuracy. Compared with previously reported cutoff values in searched literature, the 2.34 mV/106sperm/ml cutoff value identified in our study yielded the highest overall diagnostic accuracy in the evaluation of infertile men.

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  • Åberg, Cecilia
    et al.
    Högskolan i Skövde, Institutionen för hälsovetenskaper. Högskolan i Skövde, Forskningsmiljön hälsa, hållbarhet och digitalisering. School of Health and Welfare, Jönköping University, Sweden.
    Gillsjö, Catharina
    Högskolan i Skövde, Institutionen för hälsovetenskaper. Högskolan i Skövde, Forskningsmiljön hälsa, hållbarhet och digitalisering. College of Nursing, University of Rhode Island, Kingston, USA.
    Hallgren, Jenny
    Högskolan i Skövde, Institutionen för hälsovetenskaper. Högskolan i Skövde, Forskningsmiljön hälsa, hållbarhet och digitalisering. School of Health and Welfare, Jönköping University, Sweden.
    Berglund, Mia
    Högskolan i Skövde, Institutionen för hälsovetenskaper. Högskolan i Skövde, Forskningsmiljön hälsa, hållbarhet och digitalisering.
    "It is like living in a diminishing world": older persons' experiences of living with long-term health problems - prior to the STRENGTH intervention2020Inngår i: International Journal of Qualitative Studies on Health and Well-being, ISSN 1748-2623, E-ISSN 1748-2631, Vol. 15, nr 1, s. 1-12, artikkel-id 1747251Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    Introduction: Ageing is often associated with multiple long-term health problems influencing older persons' well-being in daily living. It is not unusual that the point of interest in research is often on the management of the actual health problem instead of being holistic and person-centred.Purpose: To describe the phenomenon of living with long-term health problems that influence daily living, from the older persons' perspective.Methods: Qualitative individual interviews were conducted with 34 older persons living with long-term health problems. The data were analysed using a Reflected Lifeworld Research (RLR) approach, grounded in phenomenology. Results: Life with long-term health problems entails living in a diminishing world. It entails living in uncertainty, not being able to trust one's own ability. The freedom to make decisions of your own is deprived by relatives and health-care providers. Living with long-term health problems entails being dependent on support in daily life and a strive to maintain meaningfulness in daily living.Conclusions: The results address a need for extended individual and holistic guidance and support in living with long-term health problems to increase the older person's sense of well-being and meaning in life.

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  • Alcaçoas, Dellainey
    Högskolan i Skövde, Institutionen för informationsteknologi.
    Anomaly detection in ring rolling process: Using Tree Ensemble Methods2019Independent thesis Advanced level (degree of Master (One Year)), 10 poäng / 15 hpOppgave
    Abstract [en]

    Anomaly detection has been studied for many years and has been implemented successfully in many domains. There are various approaches one could adopt to achieve this goal. The core idea behind these is to build a model that is trained in detecting patterns of anomalies. For this thesis, the objective was to detect anomalies and identify the causes for the same given the data about the process in a manufacturing setup. The scenario chosen was of a ring rolling process followed at Ovako steel company in Hofors, Sweden. An approach involving tree ensemble method coupled with manual feature engineering of multivariate time series was adopted. Through the various experiments performed, it was found that the approach was successful in detecting anomalies with an accuracy varying between 79% to 82%. To identify the causes of anomalies, feature importance using Shapley additive explanation method was implemented. Doing so, identified one feature that was very prominent and could be the potential cause for anomaly. In this report, the scope for improvement and future work has also been suggested.

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